{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:33:52Z","timestamp":1791092032262,"version":"4.1.0"},"reference-count":58,"publisher":"Rockefeller University Press","issue":"9","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,11,1]]},"abstract":"<jats:p>CD4 T helper (Th) type 1 and Th2 cells have been identified in the airways of asthmatic patients. Th2 cells are believed to contribute to pathogenesis of the disease, but the role of Th1 cells is not well defined. In a mouse model, we previously reported that transferred T cell receptor\u2013transgenic Th2 cells activated in the respiratory tract led to airway inflammation with many of the pathologic features of asthma, including airway eosinophilia and mucus production. Th1 cells caused inflammation with none of the pathology associated with asthma. In this report, we investigate the role of Th1 cells in regulating airway inflammation. When Th1 and Th2 cells are transferred together into recipient mice, there is a marked reduction in airway eosinophilia and mucus staining. To address the precise role of Th1 cells, we asked (i), Are Th2-induced responses inhibited by interferon (IFN)-\u03b3? and (ii) Can Th1 cells induce eosinophilia and mucus in the absence of IFN-\u03b3? In IFN-\u03b3 receptor\u2212\/\u2212 recipient mice exposed to inhaled antigen, the inhibitory effects of Th1 cells on both airway eosinophilia and mucus production were abolished. In the absence of IFN-\u03b3 receptor signaling, Th1 cells induced mucus but not eosinophilia. Thus, we have identified new regulatory pathways for mucus production; mucus can be induced by Th2 and non-Th2 inflammatory responses in the lung, both of which are inhibited by IFN-\u03b3. The blockade of eosinophilia and mucus production by IFN-\u03b3 likely occurs through different inhibitory pathways that are activated downstream of Th2 cytokine secretion and require IFN-\u03b3 signaling in tissue of recipient mice.<\/jats:p>","DOI":"10.1084\/jem.190.9.1309","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"1309-1318","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":191,"title":["T Helper 1 Cells and Interferon \u03b3 Regulate Allergic Airway Inflammation and Mucus Production"],"prefix":"10.1084","volume":"190","author":[{"given":"Lauren","family":"Cohn","sequence":"first","affiliation":[{"name":"aSection of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520"},{"name":"bSection of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Homer","sequence":"additional","affiliation":[{"name":"cDepartment of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520"},{"name":"dPathology and Laboratory Medicine Service, V.A. Connecticut Health Care System, West Haven, Connecticut 06516"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiqian","family":"Niu","sequence":"additional","affiliation":[{"name":"aSection of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Bottomly","sequence":"additional","affiliation":[{"name":"bSection of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1999,11,1]]},"reference":[{"key":"2023072508551855900_R1","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.4049\/jimmunol.155.5.2688","article-title":"IL-13 expression at the sites of allergen challenge in patients with asthma","volume":"155","author":"Huang","year":"1995","journal-title":"J. Immunol"},{"key":"2023072508551855900_R2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1056\/NEJM199201303260504","article-title":"Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma","volume":"326","author":"Robinson","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"2023072508551855900_R3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1164\/ajrccm\/146.1.109","article-title":"Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage","volume":"146","author":"Walker","year":"1992","journal-title":"Am. Rev. Respir. Dis."},{"key":"2023072508551855900_R4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev.immunol.17.1.255","article-title":"Immunologic basis of antigen-induced airway induced hyperresponsiveness","volume":"17","author":"Wills-Karp","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"2023072508551855900_R5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1165\/ajrcmb.14.4.8600935","article-title":"T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma","volume":"14","author":"Krug","year":"1996","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2023072508551855900_R6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1164\/ajrccm\/147.2.291","article-title":"Elevated release of tumor necrosis factor-alpha and interferon-gamma by bronchoalveolar leukocytes from patients with bronchial asthma","volume":"147","author":"Cembrzynska-Nowak","year":"1993","journal-title":"Am. Rev. Respir. Dis."},{"key":"2023072508551855900_R7","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0140-6736(94)91776-0","article-title":"A potential vaccine strategy for asthma and allied atopic diseases during early childhood","volume":"344","author":"Holt","year":"1994","journal-title":"Lancet."},{"key":"2023072508551855900_R8","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.4049\/jimmunol.154.8.4187","article-title":"Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures","volume":"154","author":"Jutel","year":"1995","journal-title":"J. Immunol."},{"key":"2023072508551855900_R9","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S0091-6749(96)70205-1","article-title":"Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma","volume":"97","author":"Durham","year":"1996","journal-title":"J. Allergy Clin. Immunol."},{"key":"2023072508551855900_R10","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1172\/JCI116633","article-title":"Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses","volume":"92","author":"Varney","year":"1993","journal-title":"J. Clin. Invest."},{"key":"2023072508551855900_R11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1126\/science.275.5296.77","article-title":"The inverse association between tuberculin responses and atopic disorder","volume":"275","author":"Shirakawa","year":"1997","journal-title":"Science."},{"key":"2023072508551855900_R12","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/S0140-6736(96)91617-7","article-title":"Measles and atopy in Guinea-Bissau","volume":"347","author":"Shaheen","year":"1996","journal-title":"Lancet."},{"key":"2023072508551855900_R13","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1084\/jem.187.4.561","article-title":"Infection of mice with Mycobacterium bovis-Bacillus Calmette-Gu\u00e9rin (BCG) suppresses allergen-induced airway eosinophilia","volume":"187","author":"Erb","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023072508551855900_R14","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1165\/ajrcmb.14.4.8600934","article-title":"The one-two of T helper cellsdoes interferon-gamma knock out the Th2 hypothesis for asthma?","volume":"14","author":"Holtzman","year":"1996","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2023072508551855900_R15","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1084\/jem.186.10.1737","article-title":"Induction of airway mucus production by T helper 2 (Th2) cellsa critical role for interleukin 4 in cell recruitment but not mucus production","volume":"186","author":"Cohn","year":"1997","journal-title":"J. Exp. Med."},{"key":"2023072508551855900_R16","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.4049\/jimmunol.161.8.3813","article-title":"IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells","volume":"161","author":"Cohn","year":"1998","journal-title":"J. Immunol."},{"key":"2023072508551855900_R17","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1126\/science.2125367","article-title":"Induction by antigen of intrathymic apoptosis of CD4+CD8+ TCRlo thymocytes in vivo","volume":"250","author":"Murphy","year":"1990","journal-title":"Science."},{"key":"2023072508551855900_R18","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.4049\/jimmunol.151.12.6742","article-title":"Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo","volume":"151","author":"Levin","year":"1993","journal-title":"J. Immunol."},{"key":"2023072508551855900_R19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1600-065X.1979.tb00289.x","article-title":"Xenogenic monoclonal antibodies to mouse lymphoid differentiation antigens","volume":"47","author":"Ledbetter","year":"1979","journal-title":"Immunol. 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Immunol."},{"key":"2023072508551855900_R22","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/315333a0","article-title":"Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1","volume":"315","author":"Ohara","year":"1985","journal-title":"Nature."},{"key":"2023072508551855900_R23","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1084\/jem.166.5.1229","article-title":"Two types of mouse helper T cell cloneIII. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies","volume":"166","author":"Cherwinski","year":"1987","journal-title":"J. Exp. Med."},{"key":"2023072508551855900_R24","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1084\/jem.158.5.1635","article-title":"The major histocompatibility complex\u2013restricted antigen receptor on T cells","volume":"158","author":"Marrack","year":"1983","journal-title":"J. Exp. Med."},{"key":"2023072508551855900_R25","volume-title":"Sterologic Methods","author":"Weibel","year":"1979"},{"key":"2023072508551855900_R26","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.4049\/jimmunol.157.8.3216","article-title":"Mucosal IFN-\u03b3 gene transfer inhibits pulmonary allergic responses in mice","volume":"157","author":"Li","year":"1996","journal-title":"J. Immunol."},{"key":"2023072508551855900_R27","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.4049\/jimmunol.152.5.2546","article-title":"Nebulized but not parenteral IFN-gamma decreases IgE production and normalizes airway function in a murine model of allergen sensitization","volume":"5","author":"Lack","year":"1994","journal-title":"J. Immunol"},{"key":"2023072508551855900_R28","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1084\/jem.177.2.573","article-title":"Interferon \u03b3 regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells","volume":"177","author":"Iwamoto","year":"1993","journal-title":"J. Exp. 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USA."},{"key":"2023072508551855900_R32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4049\/jimmunol.143.1.15","article-title":"Antiproliferative effect of IFN-\u03b3 in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-\u03b3","volume":"143","author":"Gajewski","year":"1989","journal-title":"J. Immunol."},{"key":"2023072508551855900_R33","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1084\/jem.168.2.543","article-title":"Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells","volume":"168","author":"Fernandez-Botran","year":"1988","journal-title":"J. Exp. Med."},{"key":"2023072508551855900_R34","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1084\/jem.182.5.1527","article-title":"Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice","volume":"182","author":"Gavett","year":"1995","journal-title":"J. Exp. Med."},{"key":"2023072508551855900_R35","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.4049\/jimmunol.156.8.2680","article-title":"Mice lacking the IFN-\u03b3 receptor have an impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile","volume":"156","author":"Coyle","year":"1996","journal-title":"J. Immunol."},{"key":"2023072508551855900_R36","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.4049\/jimmunol.161.6.3128","article-title":"Th2-induced eotaxin expression and eosinophilia coexist with Th1 responses at the effector stage of lung inflammation","volume":"161","author":"Li","year":"1998","journal-title":"J. Immunol."},{"key":"2023072508551855900_R37","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.4049\/jimmunol.162.4.2375","article-title":"Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma","volume":"162","author":"Randolph","year":"1999","journal-title":"J. Immunol."},{"key":"2023072508551855900_R38","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1046\/j.1365-2222.1999.00525.x","article-title":"Monitoring allergen immunotherapy of pollen-allergic patientsthe ratio of allergen-specific IgG4 to IgG1 correlates with clinical outcome","volume":"29","author":"Gehlhar","year":"1999","journal-title":"Clin. Exp. Allergy."},{"key":"2023072508551855900_R39","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1073\/pnas.92.8.3142","article-title":"Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and pentostam","volume":"92","author":"Nabors","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023072508551855900_R40","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.4049\/jimmunol.161.8.4146","article-title":"Heat-killed Listeria monocytogenes as an adjuvant converts established murine Th2-dominated immune responses into Th1-dominated responses","volume":"161","author":"Yeung","year":"1998","journal-title":"J. Immunol."},{"key":"2023072508551855900_R41","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1056\/NEJM199908123410702","article-title":"Long-term clinical efficacy of grass-pollen immunotherapy","volume":"341","author":"Durham","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"2023072508551855900_R42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI5155","article-title":"Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation","volume":"103","author":"Hansen","year":"1999","journal-title":"J. Clin. Invest."},{"key":"2023072508551855900_R43","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-065X.1997.tb00959.x","article-title":"Use of adoptive transfer of T-cell-antigen-receptor-transgenic T cell for the study of T-cell activation in vivo","volume":"156","author":"Pape","year":"1997","journal-title":"Immunol. Rev."},{"key":"2023072508551855900_R44","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1164\/ajrccm.157.1.9702074","article-title":"Interleukin-5-producing CD4+ T cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyperreactivity, and lung damage in mice","volume":"157","author":"Hogan","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2023072508551855900_R45","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.4049\/jimmunol.160.5.2393","article-title":"IL-5 is required for eosinophil recruitment, crystal deposition, and mononuclear cell recruitment during a pulmonary Cryptococcus neoformans infection in genetically susceptible mice (C57BL\/6)","volume":"160","author":"Huffnagle","year":"1998","journal-title":"J. Immunol."},{"key":"2023072508551855900_R46","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1165\/ajrcmb.13.3.7654390","article-title":"Involvement of IL-5 in a murine model of allergic pulmonary inflammationprophylactic and therapeutic effect of an anti-IL-5 antibody","volume":"13","author":"Kung","year":"1995","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2023072508551855900_R47","doi-asserted-by":"crossref","first-page":"6178","DOI":"10.4049\/jimmunol.162.10.6178","article-title":"Th2-induced airway mucus production is dependent on IL-4R\u03b1, but not on eosinophils","volume":"162","author":"Cohn","year":"1999","journal-title":"J. Immunol."},{"key":"2023072508551855900_R48","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.4049\/jimmunol.162.10.6233","article-title":"IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo","volume":"162","author":"Dabbagh","year":"1999","journal-title":"J. Immunol."},{"key":"2023072508551855900_R49","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1126\/science.282.5397.2261","article-title":"Requirement for IL-13 independently of IL-4 in experimental asthma","volume":"282","author":"Grunig","year":"1998","journal-title":"Science."},{"key":"2023072508551855900_R50","doi-asserted-by":"crossref","first-page":"7821","DOI":"10.1073\/pnas.93.15.7821","article-title":"Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lunglymphocytic and eosinophilic inflammation without airway hyperreactivity","volume":"93","author":"Rankin","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072508551855900_R51","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1126\/science.282.5397.2258","article-title":"Interleukin-13central mediator of allergic asthma","volume":"282","author":"Wills-Karp","year":"1998","journal-title":"Science."},{"key":"2023072508551855900_R52","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1172\/JCI5909","article-title":"Transgenic expression of IL-13 in murine lung causes airway inflammation, mucus hypersecretion, subendothelial fibrosis, eotaxin production and airways hyperresponsiveness to methacholine","volume":"103","author":"Zhu","year":"1999","journal-title":"J. Clin. Invest."},{"key":"2023072508551855900_R53","first-page":"635","article-title":"Quantitative study of secretory cell metaplasia induced by human neutrophil elastase in the large bronchi of hamsters","volume":"105","author":"Breuer","year":"1985","journal-title":"J. Lab. Clin. Med."},{"key":"2023072508551855900_R54","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1365-3083.1989.tb02456.x","article-title":"Gamma-interferon-mediated down-regulation of electrolyte secretion by intestinal epithelial cellsa local immune mechanism?","volume":"30","author":"Holmgren","year":"1989","journal-title":"Scand. J. Immunol."},{"key":"2023072508551855900_R55","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1172\/JCI113938","article-title":"Interferon-\u03b3 directly affects barrier function of cultured intestinal epithelial monolayers","volume":"83","author":"Madara","year":"1989","journal-title":"J. Clin. Invest."},{"key":"2023072508551855900_R56","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1093\/infdis\/167.6.1481","article-title":"T cell response to Mycobacterium tuberculosis","volume":"167","author":"Orme","year":"1993","journal-title":"J. Infect. Dis."},{"key":"2023072508551855900_R57","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1136\/thx.49.6.577","article-title":"Clonal analysis of lung and blood T cells in patients with sarcoidosis","volume":"49","author":"Garlepp","year":"1994","journal-title":"Thorax."},{"key":"2023072508551855900_R58","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.4049\/jimmunol.159.6.3034","article-title":"Cytokine patterns in tuberculous and sarcoid granulomascorrelations with histopathologic features of the granulomatous response","volume":"159","author":"Bergeron","year":"1997","journal-title":"J. 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