{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:10:03Z","timestamp":1791155403732,"version":"4.1.0"},"reference-count":31,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,2,7]]},"abstract":"<jats:p>Human herpesvirus 8 (HHV8, also known as Kaposi's sarcoma [KS]-associated herpesvirus) has been implicated as an etiologic agent for KS, an angiogenic tumor composed of endothelial, inflammatory, and spindle cells. Here, we report that transgenic mice expressing the HHV8-encoded chemokine receptor (viral G protein\u2013coupled receptor) within hematopoietic cells develop angioproliferative lesions in multiple organs that morphologically resemble KS lesions. These lesions are characterized by a spectrum of changes ranging from erythematous maculae to vascular tumors, by the presence of spindle and inflammatory cells, and by expression of vGPCR, CD34, and vascular endothelial growth factor. We conclude that vGPCR contributes to the development of the angioproliferative lesions observed in these mice and suggest that this chemokine receptor may play a role in the pathogenesis of KS in humans.<\/jats:p>","DOI":"10.1084\/jem.191.3.445","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T12:48:54Z","timestamp":1027687734000},"page":"445-454","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":342,"title":["Transgenic Expression of the Chemokine Receptor Encoded by Human Herpesvirus 8 Induces an Angioproliferative Disease Resembling Kaposi's Sarcoma"],"prefix":"10.1084","volume":"191","author":[{"given":"Tong-Yuan","family":"Yang","sequence":"first","affiliation":[{"name":"aFrom the Department of Immunology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"aFrom the Department of Immunology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Leach","sequence":"additional","affiliation":[{"name":"bFrom the Department of Drug Safety and Metabolism, Schering-Plough Research Institute, Kenilworth, New Jersey 07033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Manfra","sequence":"additional","affiliation":[{"name":"aFrom the Department of Immunology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Homey","sequence":"additional","affiliation":[{"name":"cDepartment of Immunology, DNAX Research Institute, Palo Alto, California 94304"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Wiekowski","sequence":"additional","affiliation":[{"name":"aFrom the Department of Immunology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Sullivan","sequence":"additional","affiliation":[{"name":"aFrom the Department of Immunology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Her","family":"Jenh","sequence":"additional","affiliation":[{"name":"aFrom the Department of Immunology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satwant K.","family":"Narula","sequence":"additional","affiliation":[{"name":"aFrom the Department of Immunology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W.","family":"Chensue","sequence":"additional","affiliation":[{"name":"dDepartment of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio A.","family":"Lira","sequence":"additional","affiliation":[{"name":"aFrom the Department of Immunology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2000,2,7]]},"reference":[{"key":"2023072509054605500_R1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/bjc.1969.45","article-title":"Kaposi's sarcoma in mainland Tanzaniaa report of 117 cases","volume":"23","author":"Slavin","year":"1969","journal-title":"Br. 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