{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:03:02Z","timestamp":1791306182034,"version":"4.3.1"},"reference-count":20,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,2,7]]},"abstract":"<jats:p>Human T cell leukemia virus type I (HTLV-I) is a persistent virus that causes adult T cell leukemia and tropical spastic paraparesis\/HTLV-I\u2013associated myelopathy. Studies on rabbits have shown that viral proteins encoded by the open reading frames pX-I and pX-II are required for the establishment of the persistent infection. To examine the in vivo production of these proteins in humans, we have investigated whether cytotoxic T lymphocytes isolated from HTLV-I\u2013infected individuals recognized pX-I and pX-II peptides. CD8+ T lymphocytes to pX-I and pX-II peptides were detected in HTLV-I\u2013infected individuals, whatever their clinical status, and even in the absence of any antigenic restimulation. These findings indicate that the HTLV-I pX-I and pX-II proteins are chronically synthesized in vivo, and are targets of the natural immune response to the virus.<\/jats:p>","DOI":"10.1084\/jem.191.3.567","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"567-572","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":87,"title":["Evidence for the Chronic in Vivo Production of Human T Cell Leukemia Virus Type I Rof and Tof Proteins from Cytotoxic T Lymphocytes Directed against Viral Peptides"],"prefix":"10.1084","volume":"191","author":[{"given":"Claudine","family":"Pique","sequence":"first","affiliation":[{"name":"aInstitut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U332, Institut Cochin de G\u00e9n\u00e9tique Mol\u00e9culaire, 75014 Paris, France"},{"name":"bCentre National de la Recherche Scientifique, UPR 9051,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Ureta-Vidal","sequence":"additional","affiliation":[{"name":"dUnit\u00e9 d'Immunit\u00e9 Cellulaire Antivirale, Institut Pasteur, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Gessain","sequence":"additional","affiliation":[{"name":"eUnit\u00e9 d'Oncologie Virale, Institut Pasteur, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Chancerel","sequence":"additional","affiliation":[{"name":"fEtablissement de Transfusion Sanguine, Guadeloupe, 97171 Pointe-\u00e0-Pitre, Guadeloupe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Gout","sequence":"additional","affiliation":[{"name":"gF\u00e9d\u00e9ration de Neurologie, H\u00f4pital de la Piti\u00e9-Salp\u00e9tri\u00e8re, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riad","family":"Tamouza","sequence":"additional","affiliation":[{"name":"cLaboratoire d'Immunologie et d'Histocompatibilit\u00e9, H\u00f4pital St. Louis, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frantz","family":"Agis","sequence":"additional","affiliation":[{"name":"fEtablissement de Transfusion Sanguine, Guadeloupe, 97171 Pointe-\u00e0-Pitre, Guadeloupe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Dokh\u00e9lar","sequence":"additional","affiliation":[{"name":"aInstitut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U332, Institut Cochin de G\u00e9n\u00e9tique Mol\u00e9culaire, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2000,2,7]]},"reference":[{"key":"2023072509024316300_R1","first-page":"79","article-title":"HTLV-1 oncoprotein tax and cellular transcription factors","volume":"193","author":"Yoshida","year":"1995","journal-title":"Curr. 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