{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:53:51Z","timestamp":1791420831824,"version":"4.3.3"},"reference-count":46,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,2,21]]},"abstract":"<jats:p>Natural tumor surveillance capabilities of the host were investigated in six different mouse tumor models where endogenous interleukin (IL)-12 does or does not dictate the efficiency of the innate immune response. Gene-targeted and lymphocyte subset\u2013depleted mice were used to establish the relative importance of natural killer (NK) and NK1.1+ T (NKT) cells in protection from tumor initiation and metastasis. In the models examined, CD3\u2212 NK cells were responsible for tumor rejection and protection from metastasis in models where control of major histocompatibility complex class I\u2013deficient tumors was independent of IL-12. A protective role for NKT cells was only observed when tumor rejection required endogenous IL-12 activity. In particular, T cell receptor J\u03b1281 gene-targeted mice confirmed a critical function for NKT cells in protection from spontaneous tumors initiated by the chemical carcinogen, methylcholanthrene. This is the first description of an antitumor function for NKT cells in the absence of exogenously administered potent stimulators such as IL-12 or \u03b1-galactosylceramide.<\/jats:p>","DOI":"10.1084\/jem.191.4.661","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T12:48:33Z","timestamp":1027687713000},"page":"661-668","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":670,"title":["Differential Tumor Surveillance by Natural Killer (Nk) and Nkt Cells"],"prefix":"10.1084","volume":"191","author":[{"given":"Mark J.","family":"Smyth","sequence":"first","affiliation":[{"name":"aFrom the Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin and Repatriation Medical Centre, Heidelberg, 3084 Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin Y. 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