{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:31:44Z","timestamp":1791048704573,"version":"4.1.0"},"reference-count":28,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,3,20]]},"abstract":"<jats:p>We show here that maintenance of Leishmania infections with Leishmania mexicana complex parasites (Leishmania amazonensis and Leishmania pifanoi) is impaired in the absence of circulating antibody. In these studies, we used mice genetically altered to contain no circulating antibody, with and without functional B cells. This experimental design allowed us to rule out a critical role for B cell antigen presentation in Leishmania pathogenesis. In addition, we show that mice lacking the common \u03b3 chain of Fc receptors (Fc\u03b3RI, Fc\u03b5RI, and Fc\u03b3RIII) are similarly refractory to infection with these parasites. These observations establish a critical role for antibody in the pathogenesis associated with infection by members of the L. mexicana complex.<\/jats:p>","DOI":"10.1084\/jem.191.6.1063","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"1063-1068","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":126,"title":["Internalization of <i>Leishmania mexicana<\/i> Complex Amastigotes via the Fc Receptor Is Required to Sustain Infection in Murine Cutaneous Leishmaniasis"],"prefix":"10.1084","volume":"191","author":[{"given":"Peter E.","family":"Kima","sequence":"first","affiliation":[{"name":"aDivision of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06520-8034"},{"name":"dDepartment of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520-8034"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L.","family":"Constant","sequence":"additional","affiliation":[{"name":"bDivision of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8034"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Hannum","sequence":"additional","affiliation":[{"name":"bDivision of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8034"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Colmenares","sequence":"additional","affiliation":[{"name":"dDepartment of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520-8034"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen S.","family":"Lee","sequence":"additional","affiliation":[{"name":"bDivision of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8034"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Haberman","sequence":"additional","affiliation":[{"name":"cDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8034"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Shlomchik","sequence":"additional","affiliation":[{"name":"bDivision of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8034"},{"name":"cDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8034"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"McMahon-Pratt","sequence":"additional","affiliation":[{"name":"dDepartment of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520-8034"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2000,3,20]]},"reference":[{"key":"2023072509114020800_R1","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.4049\/jimmunol.136.12.4681","article-title":"Evidence that Leishmania donovani utilizes a mannose receptor on human mononuclear phagocytes to establish intracellular parasitism","volume":"136","author":"Wilson","year":"1986","journal-title":"J. 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