{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:54:18Z","timestamp":1791215658584,"version":"4.1.0"},"reference-count":66,"publisher":"Rockefeller University Press","issue":"7","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,4,3]]},"abstract":"<jats:p>The human tyrosinase-derived peptide YMDGTMSQV is presented on the surface of human histocompatibility leukocyte antigen (HLA)-A*0201+ melanomas and has been suggested to be a tumor antigen despite the fact that tyrosinase is also expressed in melanocytes. To gain information about immunoreactivity and self-tolerance to this antigen, we established a model using the murine tyrosinase-derived homologue of this peptide FMDGTMSQV, together with transgenic mice expressing the HLA-A*0201 recombinant molecule AAD. The murine peptide was processed and presented by AAD similarly to its human counterpart. After immunization with recombinant vaccinia virus encoding murine tyrosinase, we detected a robust AAD-restricted cytotoxic T lymphocyte (CTL) response to FMDGTMSQV in AAD transgenic mice in which the entire tyrosinase gene had been deleted by a radiation-induced mutation. A residual response was observed in the AAD+tyrosinase+ mice after activation under certain conditions. At least some of these residual CTLs in AAD+tyrosinase+ mice were of high avidity and induced vitiligo upon adoptive transfer into AAD+tyrosinase+ hosts. Collectively, these data suggest that FMDGTMSQV is naturally processed and presented in vivo, and that this presentation leads to substantial but incomplete self-tolerance. The relevance of this model to an understanding of the human immune response to tyrosinase is discussed.<\/jats:p>","DOI":"10.1084\/jem.191.7.1221","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"1221-1232","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":121,"title":["Self-Tolerance to the Murine Homologue of a Tyrosinase-Derived Melanoma Antigen"],"prefix":"10.1084","volume":"191","author":[{"given":"Teresa A.","family":"Colella","sequence":"first","affiliation":[{"name":"aDepartment of Microbiology and the Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy N.J.","family":"Bullock","sequence":"additional","affiliation":[{"name":"aDepartment of Microbiology and the Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liane B.","family":"Russell","sequence":"additional","affiliation":[{"name":"bLife Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Mullins","sequence":"additional","affiliation":[{"name":"aDepartment of Microbiology and the Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem W.","family":"Overwijk","sequence":"additional","affiliation":[{"name":"cSurgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chance John","family":"Luckey","sequence":"additional","affiliation":[{"name":"aDepartment of Microbiology and the Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Pierce","sequence":"additional","affiliation":[{"name":"aDepartment of Microbiology and the Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P.","family":"Restifo","sequence":"additional","affiliation":[{"name":"cSurgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor H.","family":"Engelhard","sequence":"additional","affiliation":[{"name":"aDepartment of Microbiology and the Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2000,4,3]]},"reference":[{"key":"2023072509201390700_R1","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.4049\/jimmunol.150.7.2955","article-title":"Recognition of human melanoma cells by HLA-A2.1-restricted cytotoxic T lymphocytes is mediated by at least six shared peptide epitopes","volume":"150","author":"Slingluff","year":"1993","journal-title":"J. Immunol."},{"key":"2023072509201390700_R2","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1126\/science.7513441","article-title":"Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines","volume":"264","author":"Cox","year":"1994","journal-title":"Science."},{"key":"2023072509201390700_R3","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.4049\/jimmunol.154.8.3961","article-title":"Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression","volume":"154","author":"Kawakami","year":"1995","journal-title":"J. Immunol."},{"key":"2023072509201390700_R4","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1084\/jem.181.1.363","article-title":"Mass spectrometric identification of a naturally processed melanoma peptide recognized by CD8+ cytotoxic T lymphocytes","volume":"181","author":"Castelli","year":"1995","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R5","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1084\/jem.170.3.797","article-title":"Lysis of human melanoma cells by autologous cytolytic T cell clones. Identification of human histocompatibility antigen A2 as a restriction element for three different antigens","volume":"170","author":"Wolfel","year":"1989","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R6","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.4049\/jimmunol.142.9.3329","article-title":"The role of HLA class I antigens in recognition of melanoma cells by tumor-specific cytotoxic T lymphocytes. Evidence for shared tumor antigens","volume":"142","author":"Darrow","year":"1989","journal-title":"J. Immunol."},{"key":"2023072509201390700_R7","first-page":"153","article-title":"Common expression of melanoma tumor-associated antigens recognized by human tumor infiltrating lymphocytesanalysis by human lymphocyte antigen restriction","volume":"10","author":"Hom","year":"1991","journal-title":"J. Immunother."},{"key":"2023072509201390700_R8","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.4049\/jimmunol.151.7.3719","article-title":"Identification of human melanoma peptides recognized by class I restricted tumor infiltrating T lymphocytes","volume":"151","author":"Storkus","year":"1993","journal-title":"J. Immunol."},{"key":"2023072509201390700_R9","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1073\/pnas.91.6.2105","article-title":"Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes","volume":"91","author":"Celis","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072509201390700_R10","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1002\/eji.1830241218","article-title":"A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3","volume":"24","author":"van der Bruggen","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"2023072509201390700_R11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1074-7613(95)80053-0","article-title":"BAGEa new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes","volume":"2","author":"Boel","year":"1995","journal-title":"Immunity."},{"key":"2023072509201390700_R12","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1084\/jem.182.3.689","article-title":"A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma","volume":"182","author":"Van den Eynde","year":"1995","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R13","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/eji.1830240340","article-title":"Two tyrosinase nonapeptides recognized on HLA-A2 melanomas by autologous cytolytic T lymphocytes","volume":"24","author":"Wolfel","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"2023072509201390700_R14","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1084\/jem.178.2.489","article-title":"The tyrosinase gene codes for an antigen recognized by autologous cytotoxic T lymphocytes on HLA-A2 melanomas","volume":"178","author":"Brichard","year":"1993","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R15","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1084\/jem.183.2.527","article-title":"An HLA-A2 restricted tyrosinase antigen on melanoma cells results from post-translational modification and suggests a novel processing pathway for membrane proteins","volume":"183","author":"Skipper","year":"1996","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R16","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1084\/jem.179.3.1005","article-title":"Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes","volume":"179","author":"Bakker","year":"1994","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R17","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1084\/jem.181.2.799","article-title":"Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31\u2013restricted tumor-infiltrating lymphocytes","volume":"181","author":"Wang","year":"1995","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R18","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1084\/jem.184.6.2207","article-title":"Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes","volume":"184","author":"Wang","year":"1996","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00002371-199511000-00007","article-title":"Melanoma tumor-infiltrating lymphocytes derived from four distinct anatomic sites obtained from a single patientcomparison of functional reactivity and melanoma antigen recognition","volume":"18","author":"Yannelli","year":"1996","journal-title":"J. Immunother."},{"key":"2023072509201390700_R20","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1084\/jem.188.9.1641","article-title":"Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes","volume":"188","author":"Romero","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R21","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/(SICI)1097-0215(19960516)66:4<470::AID-IJC10>3.0.CO;2-C","article-title":"Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responsesevidence for immunoselection of antigen-loss variants in vivo","volume":"66","author":"Jager","year":"1996","journal-title":"Int. J. Cancer"},{"key":"2023072509201390700_R22","first-page":"3223","article-title":"Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1, and tyrosinase in human melanoma cell lines and in human melanocytic lesions","volume":"57","author":"de Vries","year":"1997","journal-title":"Cancer Res."},{"key":"2023072509201390700_R23","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s002620050015","article-title":"Melanomas with concordant loss of multiple melanocytic differentiation proteinsimmune escape that may be overcome by targeting unique or undefined antigens","volume":"48","author":"Slingluff","year":"2000","journal-title":"Cancer Immunol. Immunother."},{"key":"2023072509201390700_R24","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nm0398-321","article-title":"Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma","volume":"4","author":"Rosenberg","year":"1998","journal-title":"Nat. Med."},{"key":"2023072509201390700_R25","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nm0398-328","article-title":"Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells","volume":"4","author":"Nestle","year":"1998","journal-title":"Nat. Med."},{"key":"2023072509201390700_R26","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2230.1991.tb00383.x","article-title":"Prolonged survival in metastatic malignant melanoma associated with vitiligo","volume":"16","author":"Duhra","year":"1991","journal-title":"Clin. Exp. Dermatol."},{"key":"2023072509201390700_R27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0167-5699(97)84664-6","article-title":"Cancer vaccines based on the identification of genes encoding cancer regression antigens","volume":"18","author":"Rosenberg","year":"1997","journal-title":"Immunol. Today."},{"key":"2023072509201390700_R28","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0140-6736(05)61810-7","article-title":"Why tyrosinase for treatment of melanoma","volume":"350","author":"Song","year":"1997","journal-title":"Lancet."},{"key":"2023072509201390700_R29","doi-asserted-by":"crossref","first-page":"6458","DOI":"10.1073\/pnas.91.14.6458","article-title":"Identification of a human melanoma antigen recognized by tumor infiltrating lymphocytes associated with in vivo tumor rejection","volume":"91","author":"Kawakami","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072509201390700_R30","first-page":"797","article-title":"Melanoma cells and normal melanocytes share antigens recognized by HLA-A2\u2013restricted cytotoxic T cell clones from melanoma patients","volume":"170","author":"Anichini","year":"1993","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R31","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1073\/pnas.91.9.3515","article-title":"Cloning of the gene for a shared melanoma antigen recognized by autologous T cells infiltrating into tumor","volume":"91","author":"Kawakami","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072509201390700_R32","doi-asserted-by":"crossref","first-page":"208","DOI":"10.4049\/jimmunol.156.1.208","article-title":"Cytotoxic T cells directed to tumor antigens not expressed on normal melanocytes dominate HLA-A2.1-restricted immune repertoire to melanoma","volume":"156","author":"Anichini","year":"1996","journal-title":"J. Immunol."},{"key":"2023072509201390700_R33","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1084\/jem.188.6.1203","article-title":"High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo","volume":"188","author":"Ogg","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0027-5107(93)90184-H","article-title":"Molecular analysis of viable spontaneous and radiation-induced albino (c)-locus mutations in the mouse","volume":"286","author":"Rinchik","year":"1993","journal-title":"Mutat. Res."},{"key":"2023072509201390700_R35","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4049\/jimmunol.149.1.136","article-title":"Species specificity in the interaction of CD8 with the \u03b13 domain of MHC class I molecules","volume":"149","author":"Newberg","year":"1992","journal-title":"J. Immunol."},{"key":"2023072509201390700_R36","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.4049\/jimmunol.152.8.3862","article-title":"Association of human class I MHC alleles with the adenovirus E3\/19K protein","volume":"152","author":"Beier","year":"1994","journal-title":"J. Immunol."},{"key":"2023072509201390700_R37","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.4049\/jimmunol.134.6.4218","article-title":"Construction of novel class I histocompatibility antigens by interspecies exon shuffling","volume":"134","author":"Engelhard","year":"1985","journal-title":"J. Immunol."},{"key":"2023072509201390700_R38","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1084\/jem.187.1.37","article-title":"The class I antigen processing pathway for the membrane protein tyrosinase involves translation in the endoplasmic reticulum and processing in the cytosol","volume":"187","author":"Mosse","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R39","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1084\/jem.188.2.277","article-title":"gp100\/pmel 17 is a murine tumor rejection antigeninduction of \u201cself\u201d-reactive, tumoricidal T cells using high-affinity, altered peptide ligand","volume":"188","author":"Overwijk","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R40","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.4049\/jimmunol.152.6.2874","article-title":"Naturally processed peptides longer than nine amino acid residues bind to the class I MHC molecule HLA-A2.1 with high affinity and in different conformations","volume":"152","author":"Chen","year":"1994","journal-title":"J. Immunol."},{"key":"2023072509201390700_R41","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.4049\/jimmunol.156.7.2473","article-title":"Importance of MHC class I \u03b12 and \u03b13 domains in the recognition of self and non-self MHC molecules","volume":"156","author":"Newberg","year":"1996","journal-title":"J. Immunol."},{"key":"2023072509201390700_R42","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/genetics\/147.2.787","article-title":"Murine albino-deletion complexhigh-resolution microsatellite map and genetically anchored YAC framework map","volume":"147","author":"Rikke","year":"1997","journal-title":"Genetics."},{"key":"2023072509201390700_R43","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0952-7915(94)90028-0","article-title":"Structure of peptides associated with MHC class I molecules","volume":"6","author":"Engelhard","year":"1994","journal-title":"Curr. Opin. Immunol."},{"key":"2023072509201390700_R44","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.4049\/jimmunol.164.5.2354","article-title":"The density of peptides displayed by dendritic cells affects immune responses to human tyrosinase and gp100 in HLA-A2 transgenic mice","volume":"164","author":"Bullock","year":"2000","journal-title":"J. Immunol."},{"key":"2023072509201390700_R45","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1084\/jem.185.3.453","article-title":"Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma","volume":"185","author":"Bloom","year":"1997","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R46","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1073\/pnas.88.9.3777","article-title":"The mouse tyrosinase promoter is sufficient for expression in melanocytes and in the pigmented epithelium of the retina","volume":"88","author":"Kluppel","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072509201390700_R47","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF02602776","article-title":"A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma","volume":"44","author":"Gaugler","year":"1996","journal-title":"Immunogenetics."},{"key":"2023072509201390700_R48","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/(SICI)1097-0177(199604)205:4<445::AID-AJA8>3.0.CO;2-I","article-title":"Tyrosinase is a new marker for cell populations in the mouse neural tube","volume":"205","author":"Tief","year":"1996","journal-title":"Dev. Dyn."},{"key":"2023072509201390700_R49","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1432-1033.1996.0012t.x","article-title":"Tyrosinase, the key enzyme in melanin synthesis, is expressed in murine brain","volume":"241","author":"Tief","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"2023072509201390700_R50","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1600-0749.1993.tb00622.x","article-title":"Tyrosinase gene expression in human tissues","volume":"6","author":"Battyani","year":"1993","journal-title":"Pigment Cell Res."},{"key":"2023072509201390700_R51","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1084\/jem.187.10.1549","article-title":"Cross-tolerancea pathway for inducing tolerance to peripheral tissue antigens","volume":"187","author":"Heath","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R52","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1084\/jem.186.2.239","article-title":"Class I\u2013restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8+ T cells","volume":"186","author":"Kurts","year":"1997","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R53","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1084\/jem.184.3.923","article-title":"Constitutive class I\u2013restricted exogenous presentation of self antigens in vivo","volume":"184","author":"Kurts","year":"1999","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R54","doi-asserted-by":"crossref","first-page":"643","DOI":"10.4049\/jimmunol.160.2.643","article-title":"Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity","volume":"160","author":"Morgan","year":"1998","journal-title":"J. Immunol."},{"key":"2023072509201390700_R55","doi-asserted-by":"crossref","first-page":"723","DOI":"10.4049\/jimmunol.163.2.723","article-title":"Antigen concentration and precursor frequency determine the rate of CD8+ T cell tolerance to peripherally expressed antigens","volume":"163","author":"Morgan","year":"1999","journal-title":"J. Immunol."},{"key":"2023072509201390700_R56","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/intimm\/4.5.581","article-title":"Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen","volume":"4","author":"Schonrich","year":"1992","journal-title":"Int. Immunol."},{"key":"2023072509201390700_R57","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.4049\/jimmunol.150.8.3131","article-title":"Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand","volume":"150","author":"Evavold","year":"1993","journal-title":"J. Immunol."},{"key":"2023072509201390700_R58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/1074-7613(95)90074-8","article-title":"T cell receptor antagonists and partial agonists","volume":"2","author":"Jameson","year":"1995","journal-title":"Immunity."},{"key":"2023072509201390700_R59","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.4049\/jimmunol.160.12.5807","article-title":"Relationships among TCR ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells","volume":"160","author":"Hemmer","year":"1998","journal-title":"J. Immunol."},{"key":"2023072509201390700_R60","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.4049\/jimmunol.160.8.3698","article-title":"Modulation of naive T cell activation with altered peptide ligandsthe nature of the peptide and presentation in the context of costimulation are critical for a sustained response","volume":"160","author":"Rogers","year":"1998","journal-title":"J. Immunol."},{"key":"2023072509201390700_R61","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1073\/pnas.92.9.4036","article-title":"Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand","volume":"92","author":"Hollsberg","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072509201390700_R62","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1126\/science.282.5392.1338","article-title":"Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking","volume":"282","author":"Alferink","year":"1998","journal-title":"Science."},{"key":"2023072509201390700_R63","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1084\/jem.182.5.1609","article-title":"Implicating a role for immune recognition of self in tumor rejectionpassive immunization against the brown locus protein","volume":"182","author":"Hara","year":"1995","journal-title":"J. Exp. Med."},{"key":"2023072509201390700_R64","doi-asserted-by":"crossref","first-page":"14809","DOI":"10.1073\/pnas.93.25.14809","article-title":"Immune response to a differentiation antigen induced by altered antigena study of tumor rejection and autoimmunity","volume":"93","author":"Naftzger","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072509201390700_R65","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1073\/pnas.96.6.2982","article-title":"Vaccination with a recombinant vaccinia virus encoding a \u201cself\u201d antigen induces autoimmune vitiligo and tumor cell destruction in micerequirement for CD4+ T lymphocytes","volume":"96","author":"Overwijk","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072509201390700_R66","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1084\/jem.190.3.355","article-title":"Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte\/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation","volume":"190","author":"van Elsas","year":"1999","journal-title":"J. Exp. Med."}],"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/191\/7\/1221\/1698966\/991781.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/191\/7\/1221\/1698966\/991781.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T10:36:19Z","timestamp":1690281379000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/191\/7\/1221\/20162\/Self-Tolerance-to-the-Murine-Homologue-of-a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4,3]]},"references-count":66,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2000,4,3]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.191.7.1221","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,4,3]]}}}