{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:04:14Z","timestamp":1791349454503,"version":"4.3.1"},"reference-count":25,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,7,3]]},"abstract":"<jats:p>The tumor necrosis factor (TNF) family member B cell activating factor (BAFF) binds B cells and enhances B cell receptor\u2013triggered proliferation. We find that B cell maturation antigen (BCMA), a predicted member of the TNF receptor family expressed primarily in mature B cells, is a receptor for BAFF. Although BCMA was previously localized to the Golgi apparatus, BCMA was found to be expressed on the surface of transfected cells and tonsillar B cells. A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo. Moreover, culturing splenic cells in the presence of BAFF increased survival of a percentage of the B cells. These results are consistent with a role for BAFF in maintaining homeostasis of the B cell population.<\/jats:p>","DOI":"10.1084\/jem.192.1.129","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"129-136","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":330,"title":["Baff Binds to the Tumor Necrosis Factor Receptor\u2013Like Molecule B Cell Maturation Antigen and Is Important for Maintaining the Peripheral B Cell Population"],"prefix":"10.1084","volume":"192","author":[{"given":"Jeffrey S.","family":"Thompson","sequence":"first","affiliation":[{"name":"aDepartment of Molecular Genetics, Biogen, Incorporated, Cambridge, Massachusetts 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Schneider","sequence":"additional","affiliation":[{"name":"dInstitute of Biochemistry, University of Lausanne, CH-1066 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