{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:27:26Z","timestamp":1793179646404,"version":"4.5.0"},"reference-count":47,"publisher":"Rockefeller University Press","issue":"11","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,12,4]]},"abstract":"<jats:p>Leukocyte traffic through secondary lymphoid tissues is finely tuned by chemokines. We have studied the functional properties of a human T cell subset marked by the expression of CXC chemokine receptor 5 (CXCR5). Memory but not naive T cells from tonsils are CXCR5+ and migrate in response to the B cell\u2013attracting chemokine 1 (BCA-1), which is selectively expressed by reticular cells and blood vessels within B cell follicles. Tonsillar CXCR5+ T cells do not respond to other chemokines present in secondary lymphoid tissues, including secondary lymphoid tissue chemokine (SLC), EBV-induced molecule 1 ligand chemokine (ELC), and stromal cell\u2013derived factor 1 (SDF-1). The involvement of tonsillar CXCR5+ T cells in humoral immune responses is suggested by their localization in the mantle and light zone germinal centers of B cell follicles and by the concomitant expression of activation and costimulatory markers, including CD69, HLA-DR, and inducible costimulator (ICOS). Peripheral blood CXCR5+ T cells also belong to the CD4+ memory T cell subset but, in contrast to tonsillar cells, are in a resting state and migrate weakly to chemokines. CXCR5+ T cells are very inefficient in the production of cytokines but potently induce antibody production during coculture with B cells. These properties portray CXCR5+ T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (TFH).<\/jats:p>","DOI":"10.1084\/jem.192.11.1553","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"1553-1562","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":1122,"title":["Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function"],"prefix":"10.1084","volume":"192","author":[{"given":"Patrick","family":"Schaerli","sequence":"first","affiliation":[{"name":"aTheodor-Kocher Institute, University of Bern, CH-3000 Bern 9, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Willimann","sequence":"additional","affiliation":[{"name":"aTheodor-Kocher Institute, University of Bern, CH-3000 Bern 9, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alois B.","family":"Lang","sequence":"additional","affiliation":[{"name":"bBERNA, Swiss Serum and Vaccine Institute, 3018 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lipp","sequence":"additional","affiliation":[{"name":"cMolecular Tumorgenetics and Immunogenetics, Max-Delbr\u00fcck Center for Molecular Medicine, 13092 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pius","family":"Loetscher","sequence":"additional","affiliation":[{"name":"aTheodor-Kocher Institute, University of Bern, CH-3000 Bern 9, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Moser","sequence":"additional","affiliation":[{"name":"aTheodor-Kocher Institute, University of Bern, CH-3000 Bern 9, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2000,11,27]]},"reference":[{"key":"2023072509222076700_R1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/33340","article-title":"Chemokines and leukocyte traffic","volume":"392","author":"Baggiolini","year":"1998","journal-title":"Nature."},{"key":"2023072509222076700_R2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0065-2776(08)60910-4","article-title":"Chemokines and their receptors in lymphocyte traffic and HIV infection","volume":"74","author":"Loetscher","year":"2000","journal-title":"Adv. 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