{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:48:40Z","timestamp":1789883320918,"version":"4.0.1"},"reference-count":42,"publisher":"Rockefeller University Press","issue":"11","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,12,4]]},"abstract":"<jats:p>Using normal and transgenic (Tg) mice, we have shown that peritoneal B-1 cells are activated by administration of cytokines or lipopolysaccharide and migrate to other lymphoid organs where they differentiate into antibody-secreting cells. However, little is known about the process of B-1 cell migration and differentiation in vivo. We developed a mouse line by crossing the antierythrocyte antibody Tg mice (HL mice) with TCR-\u03b3\/\u03b4 Tg mice specific for a self-thymus leukemia (TL) antigen in the recombination activating gene (RAG)2\u2212\/\u2212 background. In the presence of the self-antigen, Tg \u03b3\/\u03b4 T cells increased in number and manifested activated phenotypes. Peritoneal B-1 cells in these mice migrated into mesenteric lymph nodes and differentiated into autoantibody-secreting cells, resulting in strong autoimmune hemolytic anemia. Furthermore, transfer of RAG2\u2212\/\u2212 \u00d7 HL bone marrow or peritoneal cells into the peritoneal cavity of RAG2\u2212\/\u2212 \u00d7 TCR-\u03b3\/\u03b4 Tg mice gave rise to donor-derived B-1 cells in mesenteric lymph nodes, and these cells produced the autoantibody. Thus, this study demonstrates that the migration of B-1 cells and differentiation into the antibody-secreting cells can be induced by noncognate T cell help and implies the possibility that \u03b3\/\u03b4 T cells may induce B-1 cell differentiation in vivo.<\/jats:p>","DOI":"10.1084\/jem.192.11.1577","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:54Z","timestamp":1027702134000},"page":"1577-1586","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Migration and Differentiation of Autoreactive B-1 Cells Induced by Activated \u03b3\/\u03b4 T Cells in Antierythrocyte Immunoglobulin Transgenic Mice"],"prefix":"10.1084","volume":"192","author":[{"given":"Norihiko","family":"Watanabe","sequence":"first","affiliation":[{"name":"aDepartment of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan"},{"name":"bDepartment of Gastroenterology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ikuta","sequence":"additional","affiliation":[{"name":"aDepartment of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidonia","family":"Fagarasan","sequence":"additional","affiliation":[{"name":"aDepartment of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujiro","family":"Yazumi","sequence":"additional","affiliation":[{"name":"bDepartment of Gastroenterology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Chiba","sequence":"additional","affiliation":[{"name":"bDepartment of Gastroenterology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasuku","family":"Honjo","sequence":"additional","affiliation":[{"name":"aDepartment of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2000,11,27]]},"reference":[{"key":"2023072509195288400_R1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/eji.1830160423","article-title":"Peritoneal Ly-1 B cellsgenetic control, autoantibody production, increased \u03bb light chain expression","volume":"16","author":"Hayakawa","year":"1986","journal-title":"Eur. 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