{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:47:10Z","timestamp":1791074830705,"version":"4.1.0"},"reference-count":55,"publisher":"Rockefeller University Press","issue":"11","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,12,4]]},"abstract":"<jats:p>Helicobacter pylori infection induces various gastroduodenal diseases. We examined the role of two genes, vacA and cagE, in the gastric pathogenesis induced by H. pylori using a long-term (62 wk) animal model. Reportedly, both genes are associated with the virulence of H. pylori: vacA encodes vacuolating cytotoxin, and cagE, with other genes in the cag pathogenicity islands, encodes a type IV secretion system. Mongolian gerbils were challenged in this study by a wild-type TN2 strain and its isogenic mutants of cagE or vacA. The wild-type and vacA mutants induced severe gastritis, whereas cagE mutants induced far milder changes. Gastric ulcer was induced at the highest rate (22\/23) by the wild-type TN2, followed by the vacA mutant (19\/28). No ulcer was found in the gerbils infected with the cagE mutant (0\/27) or in controls (0\/27). Intestinal metaplasia was also found in the gerbils infected with the wild-type (14\/23) or vacA mutant (15\/28). Gastric cancer developed in one gerbil with wild-type infection and in one with vacA mutant infection. In conclusion, the knocking out of the cagE gene deprived wild-type H. pylori of the pathogenicity for gastritis and gastric ulcer, suggesting that the secretion system encoded by cag pathogenicity island genes plays an essential role.<\/jats:p>","DOI":"10.1084\/jem.192.11.1601","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"1601-1610","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":228,"title":["Virulence Factors of <i>Helicobacter pylori<\/i> Responsible for Gastric Diseases in Mongolian Gerbil"],"prefix":"10.1084","volume":"192","author":[{"given":"Keiji","family":"Ogura","sequence":"first","affiliation":[{"name":"aDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan"},{"name":"bDivision of Gastroenterology, The Institute for Adult Diseases, Asahi Life Foundation, Tokyo 160-0023, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Maeda","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Nakao","sequence":"additional","affiliation":[{"name":"cPharmaceutical Research Division, Takeda Chemical Industries, Limited, Osaka 532-8686, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"cPharmaceutical Research Division, Takeda Chemical Industries, Limited, Osaka 532-8686, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Tada","sequence":"additional","affiliation":[{"name":"cPharmaceutical Research Division, Takeda Chemical Industries, Limited, Osaka 532-8686, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimasa","family":"Kyutoku","sequence":"additional","affiliation":[{"name":"cPharmaceutical Research Division, Takeda Chemical Industries, Limited, Osaka 532-8686, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Shiratori","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Omata","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2000,12,4]]},"reference":[{"key":"2023072509162302900_R1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.7326\/0003-4819-116-9-705","article-title":"Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer. 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