{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:49:34Z","timestamp":1789375774723,"version":"build-2803163510"},"reference-count":26,"publisher":"Rockefeller University Press","issue":"11","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,12,4]]},"abstract":"<jats:p>The generalized Shwartzman reaction in mice which had been primed and challenged with lipopolysaccharide (LPS) depends on interleukin (IL)-12\u2013induced interferon (IFN)-\u03b3 production at the priming stage. We examined the involvement in the priming mechanism of the unique population of V\u03b114 natural killer T (NKT) cells because they promptly produce IFN-\u03b3 after IL-12 stimulation. We report here that LPS- or IL-12\u2013primed NKT cell genetically deficient mice were found to be resistant to LPS-elicited mortality. This outcome can be attributed to the reduction of IFN-\u03b3 production, because injection of recombinant mouse IFN-\u03b3, but not injection of IL-12, effectively primed the NKT cell\u2013deficient mice. However, priming with high doses of LPS caused mortality of severe combined immunodeficiency, NKT cell\u2013deficient, and CD1-deficient mice, indicating a major contribution of NKT cells to the Shwartzman reaction elicited by low doses of LPS, whereas at higher doses of LPS NK cells play a prominent role. These results suggest that the numerically small NKT cell population of normal mice apparently plays a mandatory role in the priming stage of the generalized Shwartzman reaction.<\/jats:p>","DOI":"10.1084\/jem.192.11.1645","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"1645-1652","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Resistance of Natural Killer T Cell\u2013Deficient Mice to Systemic Shwartzman Reaction"],"prefix":"10.1084","volume":"192","author":[{"given":"Francesco","family":"Dieli","sequence":"first","affiliation":[{"name":"aDepartment of Biopathology, University of Palermo,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Sireci","sequence":"additional","affiliation":[{"name":"aDepartment of Biopathology, University of Palermo,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica","family":"Russo","sequence":"additional","affiliation":[{"name":"bInstitute for Advanced Diagnostic Methodologies, National Research Council, 90134 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"cDivision of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, Chiba 260-8670, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juraj","family":"Ivanyi","sequence":"additional","affiliation":[{"name":"dKing's College London at Guy's Medical and Dental School, London SE1 9RT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Fernandez","sequence":"additional","affiliation":[{"name":"eDepartment of Immunology, Stockholm University, S-106 91 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marita","family":"Troye-Blomberg","sequence":"additional","affiliation":[{"name":"eDepartment of Immunology, Stockholm University, S-106 91 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"De Leo","sequence":"additional","affiliation":[{"name":"aDepartment of Biopathology, University of Palermo,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Salerno","sequence":"additional","affiliation":[{"name":"aDepartment of Biopathology, University of Palermo,"},{"name":"bInstitute for Advanced Diagnostic Methodologies, National Research Council, 90134 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2000,12,4]]},"reference":[{"key":"2023072509150237700_R1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1084\/jem.180.3.907","article-title":"Interleukin 12, interferon \u03b3, and tumor necrosis factor \u03b1 are the key cytokines of the generalized Shwartzman reaction","volume":"180","author":"Ozmen","year":"1994","journal-title":"J. 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