{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:48:51Z","timestamp":1791402531764,"version":"4.3.3"},"reference-count":24,"publisher":"Rockefeller University Press","issue":"12","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,12,18]]},"abstract":"<jats:p>Expulsion of gastrointestinal nematodes is associated with pronounced mucosal mast cell (MMC) hyperplasia, differentiation, and activation, accompanied by the systemic release of MMC granule chymases (chymotrypsin-like serine proteases). The \u03b2-chymase mouse mast cell protease-1 (mMCP-1) is expressed predominantly by intraepithelial MMCs, and levels in the bloodstream and intestinal lumen are maximal at the time of worm expulsion in parasitized mice. To address the in vivo functions of MMC-specific \u03b2-chymases, we have generated transgenic mice that lack the mMCP-1 gene. They were backcrossed onto a congenic BALB\/c background to investigate the response to nematode infection. The deletion of the mMCP-1 gene is associated with significantly delayed expulsion of Trichinella spiralis and increased deposition of muscle larvae in BALB\/c mice despite the presence of normal and sometimes increased numbers of MMCs. Neither worm fecundity nor worm burdens were altered in Nippostrongylus-infected mMCP-1\u2212\/\u2212 BALB\/c mice. These data demonstrate, for the first time, that the ablation of an MMC-derived effector molecule compromises the expulsion process.<\/jats:p>","DOI":"10.1084\/jem.192.12.1849","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:54Z","timestamp":1027702134000},"page":"1849-1856","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":249,"title":["Delayed Expulsion of the Nematode <i>Trichinella spiralis<\/i>In Mice Lacking the Mucosal Mast Cell\u2013Specific Granule Chymase, Mouse Mast Cell Protease-1"],"prefix":"10.1084","volume":"192","author":[{"given":"Pamela A.","family":"Knight","sequence":"first","affiliation":[{"name":"aDepartment of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, and Wellcome Trust Centre for Research in Comparative Respiratory Medicine, University of Edinburgh, Easter Bush Veterinary Centre, Midlothian EH25 9RG, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Wright","sequence":"additional","affiliation":[{"name":"aDepartment of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, and Wellcome Trust Centre for Research in Comparative Respiratory Medicine, University of Edinburgh, Easter Bush Veterinary Centre, Midlothian EH25 9RG, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine E.","family":"Lawrence","sequence":"additional","affiliation":[{"name":"bDepartment of Immunology, Strathclyde Institute of Biological Sciences, Glasgow G4 ONR, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne Y.W.","family":"Paterson","sequence":"additional","affiliation":[{"name":"bDepartment of Immunology, Strathclyde Institute of Biological Sciences, Glasgow G4 ONR, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh R.P.","family":"Miller","sequence":"additional","affiliation":[{"name":"aDepartment of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, and Wellcome Trust Centre for Research in Comparative Respiratory Medicine, University of Edinburgh, Easter Bush Veterinary Centre, Midlothian EH25 9RG, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2000,12,18]]},"reference":[{"key":"2023072509263325900_R1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000234199","article-title":"Mucosal mast cells in the rat and man","volume":"82","author":"Enerback","year":"1987","journal-title":"Int. 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