{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:13:47Z","timestamp":1791296027408,"version":"4.1.0"},"reference-count":69,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,7,17]]},"abstract":"<jats:p>There is growing evidence that chemokines and their receptors regulate the movement and interaction of antigen-presenting cells such as dendritic cells (DCs) and T cells. We tested the hypothesis that the CC chemokine receptor (CCR)2 and CCR5 and the chemokine macrophage inflammatory protein (MIP)-1\u03b1, a ligand for CCR5, influence DC migration and localization. We found that deficiency of CCR2 but not CCR5 or MIP-1\u03b1 led to distinct defects in DC biology. Langerhans cell (skin DC) density in CCR2-null mice was normal, and their ability to migrate into the dermis was intact; however, their migration to the draining lymph nodes was markedly impaired. CCR2-null mice had lower numbers of DCs in the spleen, and this was primarily due to a reduction in the CD8\u03b11 T helper cell type 1 (Th1)-inducing subset of DCs. Additionally, there was a block in the Leishmania major infection\u2013induced relocalization of splenic DCs from the marginal zone to the T cell areas. We propose that these DC defects, in conjunction with increased expression of B lymphocyte chemoattractant, a B cell\u2013specific chemokine, may collectively contribute to the striking B cell outgrowth and Th2 cytokine\u2013biased nonhealing phenotype that we observed in CCR2-deficient mice infected with L. major. This disease phenotype in mice with an L. major\u2013resistant genetic background but lacking CCR2 is strikingly reminiscent of that observed typically in mice with an L. major\u2013susceptible genetic background. Thus, CCR2 is an important determinant of not only DC migration and localization but also the development of protective cell-mediated immune responses to L. major.<\/jats:p>","DOI":"10.1084\/jem.192.2.205","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"205-218","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":226,"title":["Cc Chemokine Receptor (Ccr)2 Is Required for Langerhans Cell Migration and Localization of T Helper Cell Type 1 (Th1)-Inducing Dendritic Cells"],"prefix":"10.1084","volume":"192","author":[{"given":"Naoko","family":"Sato","sequence":"first","affiliation":[{"name":"aSouth Texas Veterans Health Care System, Audie L. Murphy Division,"},{"name":"bDepartment of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284-7880"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil K.","family":"Ahuja","sequence":"additional","affiliation":[{"name":"aSouth Texas Veterans Health Care System, Audie L. Murphy Division,"},{"name":"bDepartment of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284-7880"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlon","family":"Quinones","sequence":"additional","affiliation":[{"name":"aSouth Texas Veterans Health Care System, Audie L. Murphy Division,"},{"name":"bDepartment of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284-7880"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vannessa","family":"Kostecki","sequence":"additional","affiliation":[{"name":"aSouth Texas Veterans Health Care System, Audie L. Murphy Division,"},{"name":"bDepartment of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284-7880"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Reddick","sequence":"additional","affiliation":[{"name":"cDepartment of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284-7880"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Melby","sequence":"additional","affiliation":[{"name":"aSouth Texas Veterans Health Care System, Audie L. 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