{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:21:13Z","timestamp":1792570873092,"version":"4.5.0"},"reference-count":28,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,8,7]]},"abstract":"<jats:p>Leukotrienes are derived from arachidonic acid and serve as mediators of inflammation and immediate hypersensitivity. Leukotriene B4 (LTB4) and leukotriene C4 (LTC4) act through G protein\u2013coupled receptors LTB4 receptor (BLTR) and Cys-LTR, respectively. To investigate the physiological role of BLTR, we produced mice with a targeted disruption of the BLTR gene. Mice deficient for BLTR (BLTR\u2212\/\u2212) developed normally and had no apparent hematopoietic abnormalities. Peritoneal neutrophils from BLTR\u2212\/\u2212 mice displayed normal responses to the inflammatory mediators C5a and platelet-activating factor (PAF) but did not respond to LTB4 for calcium mobilization or chemotaxis. Additionally, LTB4 elicited peritoneal neutrophil influx in control but not in BLTR\u2212\/\u2212 mice. Thus, BLTR is the sole receptor for LTB4-induced inflammation in mice. Neutrophil influx in a peritonitis model and acute ear inflammation in response to arachidonic acid was significantly reduced in BLTR\u2212\/\u2212 mice. In mice, intravenous administration of PAF induces immediate lethal anaphylaxis. Surprisingly, female BLTR\u2212\/\u2212 mice displayed selective survival (6 of 9; P = 0.002) relative to male (1 of 11) mice of PAF-induced anaphylaxis. These results demonstrate the role of BLTR in leukotriene-mediated acute inflammation and an unexpected sex-related involvement in PAF-induced anaphylaxis.<\/jats:p>","DOI":"10.1084\/jem.192.3.433","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"433-438","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":131,"title":["Targeted Disruption of the Leukotriene B4Receptor in Mice Reveals Its Role in Inflammation and Platelet-Activating Factor\u2013Induced Anaphylaxis"],"prefix":"10.1084","volume":"192","author":[{"given":"Bodduluri","family":"Haribabu","sequence":"first","affiliation":[{"name":"aDepartment of Medicine, Duke University Medical Center, Durham, North Carolina 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margrith W.","family":"Verghese","sequence":"additional","affiliation":[{"name":"aDepartment of Medicine, Duke University Medical Center, Durham, North Carolina 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Steeber","sequence":"additional","affiliation":[{"name":"bDepartment of Immunology, Duke University Medical Center, Durham, North Carolina 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwight D.","family":"Sellars","sequence":"additional","affiliation":[{"name":"aDepartment of Medicine, Duke University Medical Center, Durham, North Carolina 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl B.","family":"Bock","sequence":"additional","affiliation":[{"name":"cDepartment of Genetics, Duke University Medical Center, Durham, North Carolina 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Snyderman","sequence":"additional","affiliation":[{"name":"aDepartment of Medicine, Duke University Medical Center, Durham, North Carolina 27710"},{"name":"bDepartment of Immunology, Duke University Medical Center, Durham, North Carolina 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2000,8,8]]},"reference":[{"key":"2023072509230733100_R1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.2042-7158.1980.tb12985.x","article-title":"Leukotriene Ba potential mediator of inflammation","volume":"32","author":"Smith","year":"1980","journal-title":"J. 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