{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T07:13:27Z","timestamp":1772349207891,"version":"3.50.1"},"reference-count":40,"publisher":"Rockefeller University Press","issue":"7","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,10,2]]},"abstract":"<jats:p>One mechanism regulating the ability of different subsets of T helper (Th) cells to respond to cytokines is the differential expression of cytokine receptors. For example, Th2 cells express both chains of the interferon \u03b3 receptor (IFN-\u03b3R), whereas Th1 cells do not express the second chain of the IFN-\u03b3R (IFN-\u03b3R2) and are therefore unresponsive to IFN-\u03b3. To determine whether the regulation of IFN-\u03b3R2 expression, and therefore IFN-\u03b3 responsiveness, is important for the differentiation of naive CD4+ T cells into Th1 cells or for Th1 effector function, we generated mice in which transgenic (TG) expression of IFN-\u03b3R2 is controlled by the CD2 promoter and enhancer. CD4+ T cells from IFN-\u03b3R2 TG mice exhibit impaired Th1 polarization potential in vitro. TG mice also display several defects in Th1-dependent immunity in vivo, including attenuated delayed-type hypersensitivity responses and decreased antigen-specific IFN-\u03b3 production. In addition, TG mice mount impaired Th1 responses against Leishmania major, as manifested by increased parasitemia and more severe lesions than their wild-type littermates. Together, these data suggest that the sustained expression of IFN-\u03b3R2 inhibits Th1 differentiation and function. Therefore, the acquisition of an IFN-\u03b3\u2013unresponsive phenotype in Th1 cells plays a crucial role in the development and function of these cells.<\/jats:p>","DOI":"10.1084\/jem.192.7.977","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"977-986","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":50,"title":["Interferon \u03b3 Signaling Alters the Function of T Helper Type 1 Cells"],"prefix":"10.1084","volume":"192","author":[{"given":"Gregory Z.","family":"Tau","sequence":"first","affiliation":[{"name":"aIntegrated Program in Cell, Molecular and Biophysical Studies, the"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"von der Weid","sequence":"additional","affiliation":[{"name":"eDNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binfeng","family":"Lu","sequence":"additional","affiliation":[{"name":"aIntegrated Program in Cell, Molecular and Biophysical Studies, the"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Cowan","sequence":"additional","affiliation":[{"name":"bDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Kvatyuk","sequence":"additional","affiliation":[{"name":"bDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Pernis","sequence":"additional","affiliation":[{"name":"bDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Cattoretti","sequence":"additional","affiliation":[{"name":"dDepartment of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ned S.","family":"Braunstein","sequence":"additional","affiliation":[{"name":"bDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Coffman","sequence":"additional","affiliation":[{"name":"eDNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul B.","family":"Rothman","sequence":"additional","affiliation":[{"name":"bDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032"},{"name":"cDepartment of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2000,10,2]]},"reference":[{"key":"2023072509254910300_R1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.iy.07.040189.001045","article-title":"TH1 and TH2 cellsdifferent patterns of lymphokine secretion lead to different functional properties","volume":"7","author":"Mosmann","year":"1989","journal-title":"Annu. 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