{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:28:52Z","timestamp":1791350932809,"version":"4.3.1"},"reference-count":30,"publisher":"Rockefeller University Press","issue":"8","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,10,16]]},"abstract":"<jats:p>Chromosomal translocations juxtaposing the MYC protooncogene with regulatory sequences of immunoglobulin (Ig) H chain or kappa (Ig\u03ba) or lambda (Ig\u03bb) L chain genes and effecting deregulated expression of MYC are the hallmarks of human Burkitt lymphoma (BL). Here we report that lymphomas with striking similarities to BL develop in mice bearing a mutated human MYC gene controlled by a reconstructed Ig\u03bb locus encompassing all the elements required for establishment of locus control in vitro. Diffusely infiltrating lymphomas with a typical starry sky appearance occurred in multiple founders and an established line, indicating independence from positional effects. Monoclonal IgM+CD5\u2212CD23\u2212 tumors developed from an initially polyclonal population of B cells. These results demonstrate that the phenotype of B lineage lymphomas induced by MYC dysregulation is highly dependent on cooperativity among the regulatory elements that govern expression of the protooncogene and provide a new system for studying the pathogenesis of BL.<\/jats:p>","DOI":"10.1084\/jem.192.8.1183","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"1183-1190","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":191,"title":["Burkitt Lymphoma in the Mouse"],"prefix":"10.1084","volume":"192","author":[{"given":"Alexander L.","family":"Kovalchuk","sequence":"first","affiliation":[{"name":"aLaboratory of Genetics, National Cancer Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Feng","family":"Qi","sequence":"additional","affiliation":[{"name":"bLaboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted A.","family":"Torrey","sequence":"additional","affiliation":[{"name":"bLaboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lekidelu","family":"Taddesse-Heath","sequence":"additional","affiliation":[{"name":"bLaboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Feigenbaum","sequence":"additional","affiliation":[{"name":"cScience Applications International Corporation (SAIC), Frederick Cancer Research Center, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Sup","family":"Park","sequence":"additional","affiliation":[{"name":"aLaboratory of Genetics, National Cancer Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Gerbitz","sequence":"additional","affiliation":[{"name":"dInstitut f\u00fcr Klinische Molekularbiologie und Tumorgenetik, Munich 81377, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustav","family":"Klobeck","sequence":"additional","affiliation":[{"name":"eInstitut f\u00fcr Physiologische Chemie der Ludwig-Maximilian Universit\u00e4t, Munich 80336, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstanze","family":"Hoertnagel","sequence":"additional","affiliation":[{"name":"dInstitut f\u00fcr Klinische Molekularbiologie und Tumorgenetik, Munich 81377, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Polack","sequence":"additional","affiliation":[{"name":"dInstitut f\u00fcr Klinische Molekularbiologie und Tumorgenetik, Munich 81377, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg W.","family":"Bornkamm","sequence":"additional","affiliation":[{"name":"dInstitut f\u00fcr Klinische Molekularbiologie und Tumorgenetik, Munich 81377, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Janz","sequence":"additional","affiliation":[{"name":"aLaboratory of Genetics, National Cancer Institute,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Herbert C.","family":"Morse","sequence":"additional","affiliation":[{"name":"bLaboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2000,10,16]]},"reference":[{"key":"2023072509350058300_R1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/bjs.18004619704","article-title":"A sarcoma involving the jaws in African children","volume":"46","author":"Burkitt","year":"1958","journal-title":"Br. 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