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In contrast, viral strains and variants that bind with low affinity to \u03b1-DG are associated with viral replication in the red pulp, display minimal replication in CD11c+ and DEC-205+ cells, and generate a robust anti-LCMV cytotoxic T lymphocyte response that clears the virus infection. Differences in binding affinities can be mapped to a single amino acid change in the viral glycoprotein 1 ligand that binds to \u03b1-DG. These findings indicate that receptor\u2013virus interaction on dendritic cells in vivo can be an essential step in the initiation of virus-induced immunosuppression and viral persistence.<\/jats:p>","DOI":"10.1084\/jem.192.9.1249","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"1249-1260","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":238,"title":["Immunosuppression and Resultant Viral Persistence by Specific Viral Targeting of Dendritic Cells"],"prefix":"10.1084","volume":"192","author":[{"given":"Noem\u00ed","family":"Sevilla","sequence":"first","affiliation":[{"name":"aDepartment of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kunz","sequence":"additional","affiliation":[{"name":"aDepartment of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Holz","sequence":"additional","affiliation":[{"name":"aDepartment of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Lewicki","sequence":"additional","affiliation":[{"name":"aDepartment of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Homann","sequence":"additional","affiliation":[{"name":"aDepartment of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Yamada","sequence":"additional","affiliation":[{"name":"bDepartment of Physiology and Biophysics, Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, Iowa 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin P.","family":"Campbell","sequence":"additional","affiliation":[{"name":"bDepartment of Physiology and Biophysics, Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, Iowa 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"de la Torre","sequence":"additional","affiliation":[{"name":"aDepartment of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.A.","family":"Oldstone","sequence":"additional","affiliation":[{"name":"aDepartment of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2000,10,30]]},"reference":[{"key":"2023072509344420000_R1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0065-3527(08)60075-5","article-title":"Anatomy of viral persistencemechanisms of persistence and associated disease","volume":"46","author":"de la Torre","year":"1996","journal-title":"Adv. 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