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This protective effect can be transferred via influenza-immune splenocytes to naive mice and is long lived. Previous immunity to lung infection clearly plays an important and underestimated role in subsequent vaccination and infection. The data have important implications for the timing of vaccinations in certain patient groups, and may contribute to variability in disease susceptibility observed in humans.<\/jats:p>","DOI":"10.1084\/jem.192.9.1317","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"1317-1326","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":115,"title":["Influenza Virus Lung Infection Protects from Respiratory Syncytial Virus\u2013Induced Immunopathology"],"prefix":"10.1084","volume":"192","author":[{"given":"Gerhard","family":"Walzl","sequence":"first","affiliation":[{"name":"bDepartment of Respiratory Medicine, National Heart and Lung Institute at St Mary's Hospital, Edgbaston, Birmingham B15 2TS, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Tafuro","sequence":"additional","affiliation":[{"name":"dMolecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Moss","sequence":"additional","affiliation":[{"name":"cCancer Research Campaign Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TS, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.M.","family":"Openshaw","sequence":"additional","affiliation":[{"name":"bDepartment of Respiratory Medicine, National Heart and Lung Institute at St Mary's Hospital, Edgbaston, Birmingham B15 2TS, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Hussell","sequence":"additional","affiliation":[{"name":"aDepartment of Biochemistry, Centre for Molecular Microbiology and Infection, Imperial College of Science, Technology and Medicine, London SW7 2AZ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2000,11,6]]},"reference":[{"key":"2023072509401906100_R1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0140-6736(98)05104-6","article-title":"Development of allergen-specific T-cell memory in atopic and normal children","volume":"353","author":"Prescott","year":"1999","journal-title":"Lancet."},{"key":"2023072509401906100_R2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0167-5699(92)90083-J","article-title":"Induction of TH1 and TH2 responsesa key role for the \u2018natural\u2019 immune response?","volume":"13","author":"Romagnani","year":"1992","journal-title":"Immunol. 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