{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:01:46Z","timestamp":1793109706038,"version":"4.5.0"},"reference-count":43,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,2,5]]},"abstract":"<jats:p>Wild-type (WT) and targeted-mutant mice incapable of making \u03b1\u03b2 T cells, \u03b3\u03b4 T cells, class I major histocompatibility complex (MHC), class II MHC, interferon (IFN)-\u03b3, or inducible nitric oxide synthase (NOS2), were infected with Mycobacterium tuberculosis (Mtb) by aerosol, and monitored over time for their ability to (a) control infection, (b) develop histopathology at sites of infection, and (c) survive. WT mice acquired the ability to control and to hold infection at a stationary level from day 20 on. This was associated with the development of a macrophage-dominated alveolitis at sites of infection, with increased synthesis of IFN-\u03b3 and NOS2 mRNA, and with an median survival time (MST) of 258.5 d. In the absence of \u03b1\u03b2 T cells, Mtb grew progressively and rapidly to induce a necrotic, neutrophil-dominated lung pathology that killed mice with an MST of 48 d. In the absence of CD4-mediated immunity (class II\u2212\/\u2212 mice), progressive bacterial growth continued in the lungs and in other organs beyond day 20, resulting in an MST of 77 d. By contrast, in the absence of CD8 T cell\u2013mediated immunity, lung infection was controlled at a 1 log higher stationary level that induced a similar histopathologic response to that of WT mice, and resulted in an MST of 232 d.<\/jats:p>","DOI":"10.1084\/jem.193.3.271","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T12:48:33Z","timestamp":1027687713000},"page":"271-280","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":460,"title":["The Relative Importance of T Cell Subsets in Immunity and Immunopathology of Airborne\n                    <i>Mycobacterium tuberculosis<\/i>\n                    Infection in Mice"],"prefix":"10.1084","volume":"193","author":[{"given":"Tirsit","family":"Mogues","sequence":"first","affiliation":[{"name":"aThe Trudeau Institute, Saranac Lake, New York 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam E.","family":"Goodrich","sequence":"additional","affiliation":[{"name":"aThe Trudeau Institute, Saranac Lake, New York 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Ryan","sequence":"additional","affiliation":[{"name":"aThe Trudeau Institute, Saranac Lake, New York 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"LaCourse","sequence":"additional","affiliation":[{"name":"aThe Trudeau Institute, Saranac Lake, New York 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"North","sequence":"additional","affiliation":[{"name":"aThe Trudeau Institute, Saranac Lake, New York 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2001,1,29]]},"reference":[{"key":"2023072509341984000_R1","first-page":"73","article-title":"The role of T cell subsets in Mycobacterium tuberculosis infection","volume":"5","author":"Boom","year":"1996","journal-title":"Infect. 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