{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:22:47Z","timestamp":1791256967703,"version":"4.1.0"},"reference-count":74,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,3,19]]},"abstract":"<jats:p>We generated vascular cell adhesion molecule (VCAM)-1 \u201cknock-in\u201d mice and Cre recombinase transgenic mice to delete the VCAM-1 gene (vcam-1) in whole mice, thereby overcoming the embryonic lethality seen with conventional vcam-1\u2013deficient mice. vcam-1 knock-in mice expressed normal levels of VCAM-1 but showed loss of VCAM-1 on endothelial and hematopoietic cells when interbred with a \u201cTIE2Cre\u201d transgene. Analysis of peripheral blood from conditional vcam-1\u2013deficient mice revealed mild leukocytosis, including elevated immature B cell numbers. Conversely, the bone marrow (BM) had reduced immature B cell numbers, but normal numbers of pro-B cells. vcam-1\u2013deficient mice also had reduced mature IgD+ B and T cells in BM and a greatly reduced capacity to support short-term migration of transferred B cells, CD4+ T cells, CD8+ T cells, and preactivated CD4+ T cells to the BM. Thus, we report an until now unappreciated dominant role for VCAM-1 in lymphocyte homing to BM.<\/jats:p>","DOI":"10.1084\/jem.193.6.741","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"741-754","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":448,"title":["Conditional Vascular Cell Adhesion Molecule 1 Deletion in Mice"],"prefix":"10.1084","volume":"193","author":[{"given":"Pandelakis A.","family":"Koni","sequence":"first","affiliation":[{"name":"aMolecular Immunology Program, Institute of Molecular Medicine and Genetics, and Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil K.","family":"Joshi","sequence":"additional","affiliation":[{"name":"aMolecular Immunology Program, Institute of Molecular Medicine and Genetics, and Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla-Angela","family":"Temann","sequence":"additional","affiliation":[{"name":"bSection of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dian","family":"Olson","sequence":"additional","affiliation":[{"name":"dBiogen Incorporated, Boston, Massachusetts 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Burkly","sequence":"additional","affiliation":[{"name":"dBiogen Incorporated, Boston, Massachusetts 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Flavell","sequence":"additional","affiliation":[{"name":"bSection of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520"},{"name":"cHoward Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2001,3,19]]},"reference":[{"key":"2023072509355328300_R1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0092-8674(91)90279-8","article-title":"Leukocyte-endothelial cell recognitionthree (or more) steps to specificity and diversity","volume":"67","author":"Butcher","year":"1991","journal-title":"Cell."},{"key":"2023072509355328300_R2","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev.iy.11.040193.004003","article-title":"Endothelial-leukocyte adhesion molecules","volume":"11","author":"Bevilacqua","year":"1993","journal-title":"Annu. 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Pathol."},{"key":"2023072509355328300_R19","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/0016-5085(92)90015-Q","article-title":"Expression of vascular adhesion molecules in inflammatory bowel disease","volume":"3","author":"Koizumi","year":"1992","journal-title":"Gastroenterology."},{"key":"2023072509355328300_R20","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/00007890-199303000-00027","article-title":"Distribution of cell adhesion molecules (ICAM-1, VCAM-1, ELAM-1) in renal tissue during allograft rejection","volume":"55","author":"Brockmeyer","year":"1993","journal-title":"Transplantation."},{"key":"2023072509355328300_R21","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/00007890-199303000-00026","article-title":"Implications of de novo ELAM-1 and VCAM-1 expression in human cardiac allograft rejection","volume":"3","author":"Ferran","year":"1993","journal-title":"Transplantation"},{"key":"2023072509355328300_R22","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1172\/JCI116670","article-title":"Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. 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Immunol."},{"key":"2023072509355328300_R33","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1159\/000028034","article-title":"Expression of VCAM-1 in lymphocytes during the process of apoptosis","volume":"6","author":"Ishiyama","year":"1998","journal-title":"Pathobiology."},{"key":"2023072509355328300_R34","doi-asserted-by":"crossref","first-page":"14423","DOI":"10.1073\/pnas.95.24.14423","article-title":"Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow","volume":"24","author":"Frenette","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023072509355328300_R35","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1002\/eji.1830261133","article-title":"Vascular cell adhesion molecule-1 expression by hematopoiesis-supporting stromal cells is not essential for lymphoid or myeloid differentiation in vivo or in vitro","volume":"11","author":"Friedrich","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"2023072509355328300_R36","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1074-7613(00)80131-4","article-title":"\u03b14 integrins regulate the proliferation\/differentiation balance of multilineage hematopoietic progenitors in vivo","volume":"5","author":"Arroyo","year":"1999","journal-title":"Immunity."},{"key":"2023072509355328300_R37","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1083\/jcb.109.3.1321","article-title":"Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin","volume":"3","author":"Wayner","year":"1989","journal-title":"J. Cell Biol."},{"key":"2023072509355328300_R38","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0092-8674(90)90661-W","article-title":"VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4\/fibronectin binding site","volume":"4","author":"Elices","year":"1990","journal-title":"Cell."},{"key":"2023072509355328300_R39","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1016\/S0021-9258(19)39696-6","article-title":"Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin \u03b14\u03b21","volume":"7","author":"Mould","year":"1990","journal-title":"J. Biol. Chem"},{"key":"2023072509355328300_R40","doi-asserted-by":"crossref","first-page":"10241","DOI":"10.1016\/S0021-9258(18)99215-X","article-title":"Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation with distinct \u03b14 epitopes","volume":"16","author":"Pulido","year":"1991","journal-title":"J. Biol. Chem."},{"key":"2023072509355328300_R41","doi-asserted-by":"crossref","first-page":"8366","DOI":"10.1016\/S0021-9258(18)42453-2","article-title":"Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of \u03b14\u03b21 (VLA-4) and \u03b14\u03b27 on the human B cell line JY","volume":"12","author":"Chan","year":"1992","journal-title":"J. Biol. Chem."},{"key":"2023072509355328300_R42","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1083\/jcb.117.1.179","article-title":"Role of integrin \u03b14\u03b27\/\u03b14\u03b2 P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering","volume":"1","author":"Ruegg","year":"1992","journal-title":"J. Cell Biol."},{"key":"2023072509355328300_R43","doi-asserted-by":"crossref","first-page":"5550","DOI":"10.1002\/j.1460-2075.1995.tb00242.x","article-title":"Critical amino acid residues for ligand binding are clustered in a predicted \u03b2-turn of the third N-terminal repeat in the integrin \u03b14 and \u03b15 subunits","volume":"22","author":"Irie","year":"1995","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072509355328300_R44","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1084\/jem.182.2.345","article-title":"The \u03b14 integrin chain is a ligand for \u03b14\u03b27 and \u03b14\u03b21","volume":"2","author":"Altevogt","year":"1995","journal-title":"J. Exp. Med."},{"key":"2023072509355328300_R45","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1084\/jem.188.11.2187","article-title":"\u03b1d\u03b22 is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM-1)","volume":"188","author":"Grayson","year":"1998","journal-title":"J. Exp. Med"},{"key":"2023072509355328300_R46","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.4049\/jimmunol.163.4.1984","article-title":"The leukocyte integrin \u03b1D\u03b22 binds VCAM-1evidence for a binding interface between I domain and VCAM-1","volume":"163","author":"Van der Vieren","year":"1999","journal-title":"J. Immunol."},{"key":"2023072509355328300_R47","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1083\/jcb.145.2.413","article-title":"The integrin \u03b19\u03b21 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1","volume":"145","author":"Taooka","year":"1999","journal-title":"J. Cell Biol."},{"key":"2023072509355328300_R48","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1242\/dev.121.2.489","article-title":"Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice","volume":"2","author":"Kwee","year":"1995","journal-title":"Development."},{"key":"2023072509355328300_R49","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1006\/geno.1993.1480","article-title":"Structure of the murine VCAM1 gene","volume":"2","author":"Cybulsky","year":"1993","journal-title":"Genomics."},{"key":"2023072509355328300_R50","doi-asserted-by":"crossref","first-page":"5919","DOI":"10.1073\/pnas.90.13.5919","article-title":"Cytokine induction of an alternatively spliced murine vascular cell adhesion molecule (VCAM) mRNA encoding a glycosylphosphatidylinositol-anchored VCAM protein","volume":"13","author":"Terry","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023072509355328300_R51","doi-asserted-by":"crossref","first-page":"4088","DOI":"10.4049\/jimmunol.153.9.4088","article-title":"Murine VCAM-1. Molecular cloning, mapping, and analysis of a truncated form","volume":"9","author":"Kumar","year":"1994","journal-title":"J. Immunol."},{"key":"2023072509355328300_R52","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.1093\/nar\/8.24.5949","article-title":"The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene","volume":"8","author":"McKnight","year":"1980","journal-title":"Nucleic Acids Res."},{"key":"2023072509355328300_R53","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1073\/pnas.94.7.3058","article-title":"Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice","volume":"7","author":"Schlaeger","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023072509355328300_R54","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat. Genet."},{"key":"2023072509355328300_R55","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/284364a0","article-title":"Peanut lectin binding properties of germinal centres of mouse lymphoid tissue","volume":"284","author":"Rose","year":"1980","journal-title":"Nature."},{"key":"2023072509355328300_R56","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1084\/jem.189.5.855","article-title":"Lymph node germinal centers form in the absence of follicular dendritic cell networks","volume":"189","author":"Koni","year":"1999","journal-title":"J. Exp. Med."},{"key":"2023072509355328300_R57","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1182\/blood.V87.6.2212.bloodjournal8762212","article-title":"The Tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells","volume":"6","author":"Batard","year":"1996","journal-title":"Blood"},{"key":"2023072509355328300_R58","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S1074-7613(00)80665-2","article-title":"Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis","volume":"9","author":"Takakura","year":"1998","journal-title":"Immunity."},{"key":"2023072509355328300_R59","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1126\/science.285.5433.1569","article-title":"In vivo protein transductiondelivery of a biologically active protein into the mouse","volume":"285","author":"Schwarze","year":"1999","journal-title":"Science."},{"key":"2023072509355328300_R60","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1084\/jem.173.5.1213","article-title":"Resolution and characterization of pro-B and pre\u2013pro-B cell stages in normal mouse bone marrow","volume":"5","author":"Hardy","year":"1991","journal-title":"J. Exp. Med"},{"key":"2023072509355328300_R61","doi-asserted-by":"crossref","first-page":"8529","DOI":"10.1073\/pnas.90.18.8529","article-title":"Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1","volume":"18","author":"Sligh","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023072509355328300_R62","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1084\/jem.180.1.95","article-title":"Leukocytosis and resistance to septic shock in intracellular adhesion molecule 1\u2013deficient mice","volume":"180","author":"Xu","year":"1994","journal-title":"J. Exp. Med"},{"key":"2023072509355328300_R63","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1002\/(SICI)1521-4141(199806)28:06<1959::AID-IMMU1959>3.0.CO;2-4","article-title":"Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice","volume":"28","author":"Andrew","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"2023072509355328300_R64","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1084\/jem.193.6.755","article-title":"Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs B cell localization and T cell\u2013dependent humoral immune response","volume":"193","author":"Leuker","year":"2001","journal-title":"J. Exp. Med."},{"key":"2023072509355328300_R65","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.4049\/jimmunol.152.8.3760","article-title":"Adhesion through the LFA-1 (CD11\u03b1\/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells","volume":"8","author":"Koopman","year":"1994","journal-title":"J. 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