{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:27:35Z","timestamp":1791354455346,"version":"4.3.1"},"reference-count":26,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,7,16]]},"abstract":"<jats:p>The cytokine interferon (IFN)-\u03b3 regulates immune clearance of parasitic, bacterial, and viral infections; however, the underlying mechanisms are poorly understood. Recently, a family of IFN-\u03b3\u2013induced genes has been identified that encode 48-kD GTP-binding proteins that localize to the endoplasmic reticulum of cells. The prototype of this family, IGTP, has been shown to be required for host defense against acute infections with the protozoan parasite Toxoplasma gondii, but not for normal clearance of the bacterium Listeria monocytogenes and murine cytomegalovirus (MCMV). To determine whether other members of the gene family also play important roles in immune defense, we generated mice that lacked expression of the genes LRG-47 and IRG-47, and examined their responses to representative pathogens. After infection with T. gondii, LRG-47\u2013deficient mice succumbed uniformly and rapidly during the acute phase of the infection; in contrast, IRG-47\u2013deficient mice displayed only partially decreased resistance that was not manifested until the chronic phase. After infection with L. monocytogenes, LRG-47\u2013deficient mice exhibited a profound loss of resistance, whereas IRG-47\u2013deficient mice exhibited completely normal resistance. In addition, both strains displayed normal clearance of MCMV. Thus, LRG-47 and IRG-47 have vital, but distinct roles in immune defense against protozoan and bacterial infections.<\/jats:p>","DOI":"10.1084\/jem.194.2.181","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:54Z","timestamp":1027702134000},"page":"181-188","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":284,"title":["Inactivation of Lrg-47 and Irg-47 Reveals a Family of Interferon \u03b3\u2013Inducible Genes with Essential, Pathogen-Specific Roles in Resistance to Infection"],"prefix":"10.1084","volume":"194","author":[{"given":"Carmen M.","family":"Collazo","sequence":"first","affiliation":[{"name":"aImmunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George S.","family":"Yap","sequence":"additional","affiliation":[{"name":"bDepartment of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory D.","family":"Sempowski","sequence":"additional","affiliation":[{"name":"cDepartment of Medicine, Division of Rheumatology, Allergy and Clinical Immunology, Duke University, Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly C.","family":"Lusby","sequence":"additional","affiliation":[{"name":"dDepartment of Medicine and Department of Immunology, Division of Geriatrics, and Center for the Study of Aging and Human Development, Duke University, Durham, NC 27710"},{"name":"eGeriatric Research, Education, and Clinical Center, VA Medical Center, Durham, NC 27705"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lino","family":"Tessarollo","sequence":"additional","affiliation":[{"name":"fDivision of Basic Sciences, National Cancer Institute, Frederick, MD 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George F. Vande","family":"Woude","sequence":"additional","affiliation":[{"name":"gVan Andel Research Institute, Grand Rapids, MI 49503"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Sher","sequence":"additional","affiliation":[{"name":"aImmunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Taylor","sequence":"additional","affiliation":[{"name":"dDepartment of Medicine and Department of Immunology, Division of Geriatrics, and Center for the Study of Aging and Human Development, Duke University, Durham, NC 27710"},{"name":"eGeriatric Research, Education, and Clinical Center, VA Medical Center, Durham, NC 27705"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2001,7,16]]},"reference":[{"key":"2023072509481426400_R1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev.biochem.67.1.227","article-title":"How cells respond to interferons","volume":"67","author":"Stark","year":"1998","journal-title":"Annu. 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