{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:53:11Z","timestamp":1791291191878,"version":"4.3.0"},"reference-count":37,"publisher":"Rockefeller University Press","issue":"8","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,10,15]]},"abstract":"<jats:p>Continuous lymphocyte recirculation between blood and lymphoid tissues forms a basis for the function of the immune system. Lymphocyte entrance from the blood into the tissues has been thoroughly characterized, but mechanisms controlling lymphocyte exit from the lymphoid tissues via efferent lymphatics have remained virtually unknown. In this work we have identified mannose receptor (MR) on human lymphatic endothelium and demonstrate its involvement in binding of lymphocytes to lymphatic vessels. We also show that the binding requires L-selectin, and L-selectin and MR form a receptor\u2013ligand pair. On the other hand, L-selectin binds to peripheral lymph node addressins (PNAds) on high endothelial venules (HEVs) that are sites where lymphocytes enter the lymphatic organs. Interestingly, MR is absent from HEVs and PNAds from lymphatic endothelium. Thus, lymphocyte L-selectin uses distinct ligand molecules to mediate binding at sites of lymphocyte entrance and exit within lymph nodes. Taken together, interaction between L-selectin and MR is the first molecularly defined mechanism mediating lymphocyte binding to lymphatic endothelium.<\/jats:p>","DOI":"10.1084\/jem.194.8.1033","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:33Z","timestamp":1027702113000},"page":"1033-1042","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":121,"title":["Mannose Receptor Is a Novel Ligand for L-Selectin and Mediates Lymphocyte Binding to Lymphatic Endothelium"],"prefix":"10.1084","volume":"194","author":[{"given":"Heikki","family":"Irjala","sequence":"first","affiliation":[{"name":"aMediCity Research Laboratory, Department of Medical Microbiology, and National Public Health Institute, Department in Turku, and the Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva-Liz","family":"Johansson","sequence":"additional","affiliation":[{"name":"aMediCity Research Laboratory, Department of Medical Microbiology, and National Public Health Institute, Department in Turku, and the Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reidar","family":"Grenman","sequence":"additional","affiliation":[{"name":"bOtorhinolaryngology\u2013Head and Neck Surgery, University of Turku, FIN-20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalle","family":"Alanen","sequence":"additional","affiliation":[{"name":"cPathology, University of Turku, FIN-20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Salmi","sequence":"additional","affiliation":[{"name":"aMediCity Research Laboratory, Department of Medical Microbiology, and National Public Health Institute, Department in Turku, and the Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirpa","family":"Jalkanen","sequence":"additional","affiliation":[{"name":"aMediCity Research Laboratory, Department of Medical Microbiology, and National Public Health Institute, Department in Turku, and the Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2001,10,8]]},"reference":[{"key":"2023072511194867300_R1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0092-8674(91)90279-8","article-title":"Leukocyte-endothelial cell recognitionthree (or more) steps to specificity and diversity","volume":"67","author":"Butcher","year":"1991","journal-title":"Cell."},{"key":"2023072511194867300_R2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0092-8674(94)90337-9","article-title":"Traffic signals for lymphocyte recirculation and leukocyte emigrationthe multistep paradigm","volume":"76","author":"Springer","year":"1994","journal-title":"Cell."},{"key":"2023072511194867300_R3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0065-2776(08)60889-5","article-title":"How do lymphocytes know where to gocurrent concepts and enigmas of lymphocyte homing","volume":"64","author":"Salmi","year":"1997","journal-title":"Adv. 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