{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T18:54:44Z","timestamp":1648839284300},"reference-count":0,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1914,7,1]]},"abstract":"<jats:p>1. The unsaturated lipoids (serum antitrypsin) can be adsorbed from guinea pig serum, rabbit serum, and horse serum by kaolin, starch, agar, and bacteria.<\/jats:p>\n               <jats:p>2. Diphtheria toxin and cobra venom also reduce the serum antitrypsin, possibly because of their affinity for lipoids.<\/jats:p>\n               <jats:p>3. Anaphylatoxins represent sera rendered toxic by partial removal of serum antitrypsin.<\/jats:p>\n               <jats:p>4. The matrix of the protein split products lies in the serum proteins so exposed.<\/jats:p>\n               <jats:p>5. The amount of removal of serum antitrypsin depends on definite quantitative relations; very large amounts and very small amounts of adsorbing substances are least effective (kaolin, starch, and bacteria).<\/jats:p>\n               <jats:p>6. Bacteria previously treated with serum or with oils do not adsorb serum antitrypsin.<\/jats:p>\n               <jats:p>7. Bacteria treated with serum become more resistant to the action of trypsin.<\/jats:p>","DOI":"10.1084\/jem.20.1.37","type":"journal-article","created":{"date-parts":[[2004,6,17]],"date-time":"2004-06-17T22:31:16Z","timestamp":1087511476000},"page":"37-51","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["THE MECHANISM OF ANAPHYLATOXIN FORMATION"],"prefix":"10.1084","volume":"20","author":[{"given":"James W.","family":"Jobling","sequence":"first","affiliation":[{"name":"From the Department of Pathology of the College of Physicians and Surgeons, Columbia University, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Petersen","sequence":"additional","affiliation":[{"name":"From the Department of Pathology of the College of Physicians and Surgeons, Columbia University, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1914,7,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/20\/1\/37\/1208559\/37.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/20\/1\/37\/1208559\/37.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T16:19:03Z","timestamp":1601741943000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/20\/1\/37\/8480\/THE-MECHANISM-OF-ANAPHYLATOXIN-FORMATION-STUDIES"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1914,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1914,7,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20.1.37","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1914,7,1]]}}}