{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:05:49Z","timestamp":1791198349306,"version":"4.1.0"},"reference-count":70,"publisher":"Rockefeller University Press","issue":"7","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,4,1]]},"abstract":"<jats:p>The function of the intraepithelial lymphocyte (IEL) network of T cell receptor (TCR) \u03b3\u03b4+ (V\u03b35+) dendritic epidermal T cells (DETC) was evaluated by examining several mouse strains genetically deficient in \u03b3\u03b4 T cells (\u03b4\u2212\/\u2212 mice), and in \u03b4\u2212\/\u2212 mice reconstituted with DETC or with different \u03b3\u03b4 cell subpopulations. NOD.\u03b4\u2212\/\u2212 and FVB.\u03b4\u2212\/\u2212 mice spontaneously developed localized, chronic dermatitis, whereas interestingly, the commonly used C57BL\/6.\u03b4\u2212\/\u2212 strain did not. Genetic analyses indicated a single autosomal recessive gene controlled the dermatitis susceptibility of NOD.\u03b4\u2212\/\u2212 mice. Furthermore, allergic and irritant contact dermatitis reactions were exaggerated in FVB.\u03b4\u2212\/\u2212, but not in C57BL\/6.\u03b4\u2212\/\u2212 mice. Neither spontaneous nor augmented irritant dermatitis was observed in FVB.\u03b2\u2212\/\u2212 \u03b4\u2212\/\u2212 mice lacking all T cells, indicating that \u03b1\u03b2 T cell\u2013mediated inflammation is the target for \u03b3\u03b4-mediated down-regulation. Reconstitution studies demonstrated that both spontaneous and augmented irritant dermatitis in FVB.\u03b4\u2212\/\u2212 mice were down-regulated by V\u03b35+ DETC, but not by epidermal T cells expressing other \u03b3\u03b4 TCRs. This study demonstrates that functional impairment at an epithelial interface can be specifically attributed to absence of the local TCR-\u03b3\u03b4+ IEL subset and suggests that systemic inflammatory reactions may more generally be subject to substantial regulation by local IELs.<\/jats:p>","DOI":"10.1084\/jem.20012000","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:48:54Z","timestamp":1027702134000},"page":"855-867","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":178,"title":["Resident Skin-specific \u03b3\u03b4 T Cells Provide Local, Nonredundant Regulation of Cutaneous Inflammation"],"prefix":"10.1084","volume":"195","author":[{"given":"Michael","family":"Girardi","sequence":"first","affiliation":[{"name":"1Department of Dermatology and the Yale Skin Diseases Research Core Center, Yale University, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Lewis","sequence":"additional","affiliation":[{"name":"1Department of Dermatology and the Yale Skin Diseases Research Core Center, Yale University, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earl","family":"Glusac","sequence":"additional","affiliation":[{"name":"1Department of Dermatology and the Yale Skin Diseases Research Core Center, Yale University, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata B.","family":"Filler","sequence":"additional","affiliation":[{"name":"1Department of Dermatology and the Yale Skin Diseases Research Core Center, Yale University, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Geng","sequence":"additional","affiliation":[{"name":"2Section of Immunobiology, Yale University, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian C.","family":"Hayday","sequence":"additional","affiliation":[{"name":"3Peter Gorer Department of Immunobiology, Guy's King's St. Thomas' School of Medicine, Guy's Hospital, London, United Kingdom SE1 9RT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Tigelaar","sequence":"additional","affiliation":[{"name":"1Department of Dermatology and the Yale Skin Diseases Research Core Center, Yale University, New Haven, CT 06520"},{"name":"2Section of Immunobiology, Yale University, New Haven, CT 06520"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2002,4,1]]},"reference":[{"key":"2023072511291187900_BIB1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0952-7915(98)80084-8","volume":"10","year":"1998","journal-title":"Curr. 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