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To determine the significance of earlier findings that expression of the tumor suppressor ICSBP is often downregulated in AML myeloblasts, AML1-ETO was introduced into BM cells derived from mice lacking the interferon regulatory factor ICSBP. Our findings demonstrate that AML1-ETO synergizes with an ICSBP deficiency to induce myeloblastic transformation in the BM, reminiscent of AML.<\/jats:p>","DOI":"10.1084\/jem.20020824","type":"journal-article","created":{"date-parts":[[2002,11,4]],"date-time":"2002-11-04T17:42:44Z","timestamp":1036431764000},"page":"1227-1240","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":124,"title":["AML1-ETO Inhibits Maturation of Multiple Lymphohematopoietic Lineages and Induces Myeloblast Transformation in Synergy with ICSBP Deficiency"],"prefix":"10.1084","volume":"196","author":[{"given":"Maike","family":"Schwieger","sequence":"first","affiliation":[{"name":"1Department of Cell and Virus Genetics, Heinrich-Pette-Institut fu\u0308r Experimentelle Virologie und Immunologie, D-20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u0308rgen","family":"Lo\u0308hler","sequence":"additional","affiliation":[{"name":"2Molecular Pathology Group, Heinrich-Pette-Institut fu\u0308r Experimentelle Virologie und Immunologie, D-20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta","family":"Friel","sequence":"additional","affiliation":[{"name":"1Department of Cell and Virus Genetics, Heinrich-Pette-Institut fu\u0308r Experimentelle Virologie und Immunologie, D-20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Scheller","sequence":"additional","affiliation":[{"name":"3Department of Molecular Genetics, Institute of Molecular Pharmacology, Freie Universita\u0308t Berlin, D-12207 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Horak","sequence":"additional","affiliation":[{"name":"3Department of Molecular Genetics, Institute of Molecular Pharmacology, Freie Universita\u0308t Berlin, D-12207 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Stocking","sequence":"additional","affiliation":[{"name":"1Department of Cell and Virus Genetics, Heinrich-Pette-Institut fu\u0308r Experimentelle Virologie und Immunologie, D-20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2002,11,4]]},"reference":[{"key":"2023072511480025600_BIB1"},{"key":"2023072511480025600_BIB2","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1182\/blood.V80.7.1825.1825","volume":"80","year":"1992","journal-title":"Blood."},{"key":"2023072511480025600_BIB3","doi-asserted-by":"crossref","first-page":"10431","DOI":"10.1073\/pnas.88.23.10431","volume":"88","year":"1991","journal-title":"Proc. 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