{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:04:02Z","timestamp":1791295442184,"version":"4.1.0"},"reference-count":30,"publisher":"Rockefeller University Press","issue":"8","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,10,21]]},"abstract":"<jats:p>A characteristic of the three human-pathogenic Yersinia spp. (the plague agent Yersinia pestis and the enteropathogenic Yersinia pseudotuberculosis and Yersinia enterocolitica) is the expression of the virulence (V)-antigen (LcrV). LcrV is a released protein which is involved in contact-induced secretion of yersinia antihost proteins and in evasion of the host's innate immune response. Here we report that recombinant LcrV signals in a CD14- and toll-like receptor 2 (TLR2)-dependent fashion leading to immunosuppression by interleukin 10 induction. The impact of this immunosuppressive effect for yersinia pathogenesis is underlined by the observation that TLR2-deficient mice are less susceptible to oral Y. enterocolitica infection than isogenic wild-type animals. In summary, these data demonstrate a new ligand specificity of TLR2, as LcrV is the first known secreted and nonlipidated virulence-associated protein of a Gram-negative bacterium using TLR2 for cell activation. We conclude that yersiniae might exploit host innate pattern recognition molecules and defense mechanisms to evade the host immune response.<\/jats:p>","DOI":"10.1084\/jem.20020908","type":"journal-article","created":{"date-parts":[[2002,10,21]],"date-time":"2002-10-21T19:24:57Z","timestamp":1035228297000},"page":"1017-1024","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":257,"title":["Yersinia V\u2013Antigen Exploits Toll-like Receptor 2 and CD14 for Interleukin 10\u2013mediated Immunosuppression"],"prefix":"10.1084","volume":"196","author":[{"given":"Andreas","family":"Sing","sequence":"first","affiliation":[{"name":"1Max von Pettenkofer-Institut fu\u0308r Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen, Pettenkoferstrasse 9a, 80336 Mu\u0308nchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Rost","sequence":"additional","affiliation":[{"name":"1Max von Pettenkofer-Institut fu\u0308r Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen, Pettenkoferstrasse 9a, 80336 Mu\u0308nchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Tvardovskaia","sequence":"additional","affiliation":[{"name":"1Max von Pettenkofer-Institut fu\u0308r Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen, Pettenkoferstrasse 9a, 80336 Mu\u0308nchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Roggenkamp","sequence":"additional","affiliation":[{"name":"1Max von Pettenkofer-Institut fu\u0308r Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen, Pettenkoferstrasse 9a, 80336 Mu\u0308nchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agne\u0300s","family":"Wiedemann","sequence":"additional","affiliation":[{"name":"1Max von Pettenkofer-Institut fu\u0308r Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen, Pettenkoferstrasse 9a, 80336 Mu\u0308nchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten J.","family":"Kirschning","sequence":"additional","affiliation":[{"name":"2Institut fu\u0308r Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universita\u0308t Mu\u0308nchen, Trogerstrasse 32, 81675 Mu\u0308nchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Aepfelbacher","sequence":"additional","affiliation":[{"name":"1Max von Pettenkofer-Institut fu\u0308r Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen, Pettenkoferstrasse 9a, 80336 Mu\u0308nchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u0308rgen","family":"Heesemann","sequence":"additional","affiliation":[{"name":"1Max von Pettenkofer-Institut fu\u0308r Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen, Pettenkoferstrasse 9a, 80336 Mu\u0308nchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2002,10,14]]},"reference":[{"key":"2023072511483296000_BIB1","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1128\/MMBR.62.4.1315-1352.1998","volume":"62","year":"1998","journal-title":"Microbiol. 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