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Analysis of mixed bone marrow chimeras established that the mutation affects a cell autonomous process within B cells that is required for their accumulation after emigrating to peripheral lymphoid organs. The defect is caused by a point mutation in the gene encoding transcription factor nuclear factor (NF)-\u03baB2, terminating the encoded protein within the DNA-binding domain. These findings establish the feasibility of analyzing immune regulation by genome wide mutant screens and demonstrates an intrinsic requirement for NF-\u03baB2 in regulating circulating follicular B cell numbers.<\/jats:p>","DOI":"10.1084\/jem.20020959","type":"journal-article","created":{"date-parts":[[2002,10,21]],"date-time":"2002-10-21T19:24:57Z","timestamp":1035228297000},"page":"1113-1119","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":51,"title":["Analysis of an Ethylnitrosourea-generated Mouse Mutation Defines a Cell Intrinsic Role of Nuclear Factor \u03baB2 in Regulating Circulating B Cell Numbers"],"prefix":"10.1084","volume":"196","author":[{"given":"Lisa A.","family":"Miosge","sequence":"first","affiliation":[{"name":"Australian Cancer Research Foundation Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Blasioli","sequence":"additional","affiliation":[{"name":"Australian Cancer Research Foundation Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Blery","sequence":"additional","affiliation":[{"name":"Australian Cancer Research Foundation Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Goodnow","sequence":"additional","affiliation":[{"name":"Australian Cancer Research Foundation Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2002,10,21]]},"reference":[{"key":"2023072511435976700_BIB1","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.1073\/pnas.82.19.6619","volume":"82","year":"1985","journal-title":"Proc. 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