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Long-term survival after viral but not bacterial infection was increased \u223c100-fold by FL treatment. After treatment, CD11c+\/major histocompatibility complex type II+ and CD11c+\/B220+ DC lineage cells were the only cell populations increased in the spleen, liver, peritoneum, and skin. DC induction was independent of IFNs, IL-2, -4, -7, -9, -15, and mature T and B cells. The data suggest that FL increases the number of DCs in neonates and possibly in other immune-compromised individuals, which in turn improves IFN-\u03b1\/\u03b2\u2013 and IL-12\u2013associated immune responses.<\/jats:p>","DOI":"10.1084\/jem.20021900","type":"journal-article","created":{"date-parts":[[2003,3,3]],"date-time":"2003-03-03T18:44:12Z","timestamp":1046717052000},"page":"575-584","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":53,"title":["Flt3 Ligand\u2013treated Neonatal Mice Have Increased Innate Immunity Against Intracellular Pathogens and Efficiently Control Virus Infections"],"prefix":"10.1084","volume":"197","author":[{"given":"Sabine","family":"Vollstedt","sequence":"first","affiliation":[{"name":"1Institute of Virology, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Franchini","sequence":"additional","affiliation":[{"name":"1Institute of Virology, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans P.","family":"Hefti","sequence":"additional","affiliation":[{"name":"1Institute of Virology, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Odermatt","sequence":"additional","affiliation":[{"name":"2Institute of Pathology, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"O'Keeffe","sequence":"additional","affiliation":[{"name":"3The Walter and Eliza Hall Institute of Medical Research, 3050 Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gottfried","family":"Alber","sequence":"additional","affiliation":[{"name":"4Institute of Immunology, University of Leipzig, D-04109 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Glanzmann","sequence":"additional","affiliation":[{"name":"1Institute of Virology, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Riesen","sequence":"additional","affiliation":[{"name":"1Institute of Virology, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Ackermann","sequence":"additional","affiliation":[{"name":"1Institute of Virology, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Suter","sequence":"additional","affiliation":[{"name":"1Institute of Virology, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2003,3,3]]},"reference":[{"key":"2023072511544475700_BIB1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1084\/jem.154.1.199","volume":"154","year":"1981","journal-title":"J. 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