{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T12:12:29Z","timestamp":1779279149983,"version":"3.51.4"},"reference-count":30,"publisher":"Rockefeller University Press","issue":"9","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,5,5]]},"abstract":"<jats:p>Mice deficient for the transcriptional coactivator BOB.1\/OBF.1 show several defects in B cell differentiation. Numbers of immature transitional B cells in the bone marrow are reduced and fewer B cells reach the periphery. Furthermore, germinal center B cells are absent and marginal zone (MZ) B lymphocytes are markedly reduced. Increased levels of B cell apoptosis in these mice prompted us to analyze expression and function of antiapoptotic proteins. Bcl2 expression is strongly reduced in BOB.1\/OBF.1-deficient pre\u2013B cells. When BOB.1\/OBF.1-deficient mice were crossed with Bcl2-transgenic mice, B cell development in the bone marrow and numbers of B cells in peripheral lymphoid organs were normalized. However, neither germinal center B cells nor MZ B cells were rescued. Additionally, Bcl2 did not rescue the defects in signaling and affinity maturation found in BOB.1\/OBF.1-deficient mice. Interestingly, Bcl2-transgenic mice by themselves show an MZ B cell defect. Virtually no functional MZ B cells were detected in these mice. In contrast, mice deficient for Bcl2 show a relative increase in MZ B cell numbers, indicating a previously undetected function of Bcl2 for this B cell compartment.<\/jats:p>","DOI":"10.1084\/jem.20022014","type":"journal-article","created":{"date-parts":[[2003,5,5]],"date-time":"2003-05-05T18:33:55Z","timestamp":1052159635000},"page":"1205-1211","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["B Cell\u2013specific Transgenic Expression of Bcl2 Rescues Early B Lymphopoiesis but Not B Cell Responses in BOB.1\/OBF.1-deficient Mice"],"prefix":"10.1084","volume":"197","author":[{"given":"Cornelia","family":"Brunner","sequence":"first","affiliation":[{"name":"1Department of Physiological Chemistry, University of Ulm, D-89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Marinkovic","sequence":"additional","affiliation":[{"name":"1Department of Physiological Chemistry, University of Ulm, D-89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u0308rg","family":"Klein","sequence":"additional","affiliation":[{"name":"2Institute of Virology and Immunobiology, University of Wuerzburg, D-97078 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Samardzic","sequence":"additional","affiliation":[{"name":"1Department of Physiological Chemistry, University of Ulm, D-89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Nitschke","sequence":"additional","affiliation":[{"name":"2Institute of Virology and Immunobiology, University of Wuerzburg, D-97078 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Wirth","sequence":"additional","affiliation":[{"name":"1Department of Physiological Chemistry, University of Ulm, D-89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2003,5,5]]},"reference":[{"key":"2023072511584202400_BIB1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0092-8674(92)90352-D","volume":"71","year":"1992","journal-title":"Cell."},{"key":"2023072511584202400_BIB2","doi-asserted-by":"crossref","first-page":"29870","DOI":"10.1074\/jbc.270.50.29870","volume":"270","year":"1995","journal-title":"J. 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