{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:19:53Z","timestamp":1791332393817,"version":"4.3.1"},"reference-count":28,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,9,15]]},"abstract":"<jats:p>The cellular source of B cell activation factor (BAFF) required for peripheral B cell survival\/maturation is unknown. To determine the nature of BAFF-producing cells we established and analyzed reciprocal bone marrow (BM) chimeras with wild-type (WT) and BAFF-deficient mice. The results revealed that BAFF production by radiation-resistant stromal cells is completely sufficient to provide a necessary signal for B cell survival\/maturation, as BAFF\u2212\/\u2212 BM cells transferred into lethally irradiated WT mice gave rise to normal numbers of follicular (FO) and marginal zone (MZ) B cell subpopulations. On the other hand, transfer of WT BM into BAFF\u2212\/\u2212 lethally irradiated mice resulted only in minimal reconstitution of mature FO B cells and no restoration of MZ B cells. Thus, in the absence of BAFF+\/+ stromal cells, BAFF production by BM-derived cells, presumably by macrophages, dendritic cells, and\/or neutrophils, was not at all sufficient to support normal B cell homeostasis. Interestingly, immunization of both types of chimeras stimulated high levels of antigen-specific antibody secretion, indicating that either stromal cell\u2013 or hematopoietic cell\u2013derived BAFF is sufficient for B cell antibody responses.<\/jats:p>","DOI":"10.1084\/jem.20030789","type":"journal-article","created":{"date-parts":[[2003,9,15]],"date-time":"2003-09-15T21:52:19Z","timestamp":1063662739000},"page":"937-945","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":221,"title":["Normal B Cell Homeostasis Requires B Cell Activation Factor Production by Radiation-resistant Cells"],"prefix":"10.1084","volume":"198","author":[{"given":"Leonid","family":"Gorelik","sequence":"first","affiliation":[{"name":"Biogen Inc., Cambridge, MA 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Gilbride","sequence":"additional","affiliation":[{"name":"Biogen Inc., Cambridge, MA 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Dobles","sequence":"additional","affiliation":[{"name":"Biogen Inc., Cambridge, MA 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Kalled","sequence":"additional","affiliation":[{"name":"Biogen Inc., Cambridge, MA 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zandman","sequence":"additional","affiliation":[{"name":"Biogen Inc., Cambridge, MA 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin L.","family":"Scott","sequence":"additional","affiliation":[{"name":"Biogen Inc., Cambridge, MA 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2003,9,15]]},"reference":[{"key":"2023072512121883400_BIB1","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/jlb.65.5.680","volume":"65","year":"1999","journal-title":"J. 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