{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:34:06Z","timestamp":1791239646379,"version":"4.1.0"},"reference-count":28,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,1,19]]},"abstract":"<jats:p>Base substitutions, deletions, and duplications are observed at the immunoglobulin locus in DNA sequences involved in class switch recombination (CSR). These mutations are dependent upon activation-induced cytidine deaminase (AID) and present all the characteristics of the ones observed during V gene somatic hypermutation, implying that they could be generated by the same mutational complex. It has been proposed, based on the V gene mutation pattern of patients with the cancer-prone xeroderma pigmentosum variant (XP-V) syndrome who are deficient in DNA polymerase \u03b7 (pol \u03b7), that this enzyme could be responsible for a large part of the mutations occurring on A\/T bases. Here we show, by analyzing switched memory B cells from two XP-V patients, that pol \u03b7 is also an A\/T mutator during CSR, in both the switch region of tandem repeats as well as upstream of it, thus suggesting that the same error-prone translesional polymerases are involved, together with AID, in both processes.<\/jats:p>","DOI":"10.1084\/jem.20031831","type":"journal-article","created":{"date-parts":[[2004,1,20]],"date-time":"2004-01-20T20:07:52Z","timestamp":1074629272000},"page":"265-270","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":113,"title":["DNA Polymerase \u03b7 Is Involved in Hypermutation Occurring during Immunoglobulin Class Switch Recombination"],"prefix":"10.1084","volume":"199","author":[{"given":"Ahmad","family":"Faili","sequence":"first","affiliation":[{"name":"1INSERM U373, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades, Universite\u0301 Paris V, 75730 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said","family":"Aoufouchi","sequence":"additional","affiliation":[{"name":"1INSERM U373, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades, Universite\u0301 Paris V, 75730 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Weller","sequence":"additional","affiliation":[{"name":"1INSERM U373, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades, Universite\u0301 Paris V, 75730 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franc\u0327oise","family":"Vuillier","sequence":"additional","affiliation":[{"name":"2Unite\u0301 d'Immuno-He\u0301matologie et d'Immunopathologie, Institut Pasteur, 75724 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Stary","sequence":"additional","affiliation":[{"name":"3Etude des Relations Instabilite\u0301 Ge\u0301ne\u0301tique et Cancer, CNRS UPR 2169, Institut Gustave Roussy, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Sarasin","sequence":"additional","affiliation":[{"name":"3Etude des Relations Instabilite\u0301 Ge\u0301ne\u0301tique et Cancer, CNRS UPR 2169, Institut Gustave Roussy, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude-Agne\u0300s","family":"Reynaud","sequence":"additional","affiliation":[{"name":"1INSERM U373, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades, Universite\u0301 Paris V, 75730 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Weill","sequence":"additional","affiliation":[{"name":"1INSERM U373, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades, Universite\u0301 Paris V, 75730 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2004,1,20]]},"reference":[{"key":"2023072512183334400_BIB1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.immunol.20.090501.112049","volume":"20","year":"2002","journal-title":"Annu. 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