{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:28:29Z","timestamp":1791332909973,"version":"4.3.1"},"reference-count":50,"publisher":"Rockefeller University Press","issue":"10","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,5,17]]},"abstract":"<jats:p>Human T lymphocyte virus type I (HTLV-I)\u2013associated chronic inflammatory neurological disease (HTLV-I\u2013associated myelopathy\/tropical spastic paraparesis [HAM\/TSP]) is suggested to be an immunopathologically mediated disorder characterized by large numbers of HTLV-I Tax\u2013specific CD8+ T cells. The frequency of these cells in the peripheral blood and cerebrospinal fluid is proportional to the amount of HTLV-I proviral load and the levels of HTLV-I tax mRNA expression. As the stimulus for these virus-specific T cells are immunodominant peptide\u2013human histocompatibility leukocyte antigen (HLA) complexes expressed on antigen-presenting cells, it was of interest to determine which cells express these complexes and at what frequency. However, until now, it has not been possible to identify and\/or quantify these peptide\u2013HLA complexes. Using a recently developed antibody that specifically recognizes Tax11-19 peptide\u2013HLA-A*201 complexes, the level of Tax11-19\u2013HLA-A*201 expression on T cells was demonstrated to be increased in HAM\/TSP and correlated with HTLV-I proviral DNA load, HTLV-I tax mRNA load, and HTLV-I Tax\u2013specific CD8+ T cell frequencies. Furthermore, CD4+ CD25+ T cells were demonstrated to be the major reservoir of HTLV-I provirus as well as Tax11-19 peptide\u2013HLA-A*201 complexes. These results indicate that the increased detection and visualization of peptide\u2013HLA complexes in HAM\/TSP CD4+ CD25+ T cell subsets that are shown to stimulate and expand HTLV-I Tax\u2013specific CD8+ T cells may play an important role in the pathogenesis of HTLV-I\u2013associated neurological disease.<\/jats:p>","DOI":"10.1084\/jem.20032042","type":"journal-article","created":{"date-parts":[[2004,5,10]],"date-time":"2004-05-10T21:03:57Z","timestamp":1084223037000},"page":"1367-1377","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":102,"title":["Increased Expression of Human T Lymphocyte Virus Type I (HTLV-I) Tax11-19 Peptide\u2013Human Histocompatibility Leukocyte Antigen A*201 Complexes on CD4+ CD25\n                    <b>+<\/b>\n                    T Cells Detected by Peptide-specific, Major Histocompatibility Complex\u2013restricted Antibodies in Patients with HTLV-I\u2013associated Neurologic Disease"],"prefix":"10.1084","volume":"199","author":[{"given":"Yoshihisa","family":"Yamano","sequence":"first","affiliation":[{"name":"1Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"2Faculty of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiro","family":"Takenouchi","sequence":"additional","affiliation":[{"name":"1Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Yao","sequence":"additional","affiliation":[{"name":"1Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utano","family":"Tomaru","sequence":"additional","affiliation":[{"name":"1Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892"},{"name":"3Department of Pathology\/Pathophysiology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Chuan","family":"Li","sequence":"additional","affiliation":[{"name":"4Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoram","family":"Reiter","sequence":"additional","affiliation":[{"name":"2Faculty of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Jacobson","sequence":"additional","affiliation":[{"name":"1Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2004,5,10]]},"reference":[{"key":"2023072512184335400_BIB1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1089\/aid.1993.9.381","volume":"9","year":"1993","journal-title":"AIDS Res. Hum. Retroviruses."},{"key":"2023072512184335400_BIB2","first-page":"1031","volume":"1","year":"1986","journal-title":"Lancet."},{"key":"2023072512184335400_BIB3","first-page":"407","volume":"2","year":"1985","journal-title":"Lancet."},{"key":"2023072512184335400_BIB4","first-page":"1096","volume":"3","year":"1990","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"2023072512184335400_BIB5","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1089\/aid.1992.8.651","volume":"8","year":"1992","journal-title":"AIDS Res. Hum. Retroviruses."},{"key":"2023072512184335400_BIB6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1146\/annurev.immunol.15.1.15","volume":"15","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"2023072512184335400_BIB7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/348245a0","volume":"348","year":"1990","journal-title":"Nature."},{"key":"2023072512184335400_BIB8","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1084\/jem.177.6.1567","volume":"177","year":"1993","journal-title":"J. Exp. Med."},{"key":"2023072512184335400_BIB9","doi-asserted-by":"crossref","first-page":"482","DOI":"10.4049\/jimmunol.161.1.482","volume":"161","year":"1998","journal-title":"J. Immunol."},{"key":"2023072512184335400_BIB10","first-page":"197","volume":"183","year":"2000","journal-title":"J. Infect. Dis."},{"key":"2023072512184335400_BIB11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1182\/blood.V99.1.88","volume":"99","year":"2002","journal-title":"Blood."},{"key":"2023072512184335400_BIB12","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.4049\/jimmunol.151.7.3874","volume":"151","year":"1993","journal-title":"J. Immunol."},{"key":"2023072512184335400_BIB13","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1128\/jvi.68.5.2860-2868.1994","volume":"68","year":"1994","journal-title":"J. Virol."},{"key":"2023072512184335400_BIB14","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.4049\/jimmunol.159.4.2018","volume":"159","year":"1997","journal-title":"J. Immunol."},{"key":"2023072512184335400_BIB15","doi-asserted-by":"crossref","first-page":"7568","DOI":"10.1073\/pnas.95.13.7568","volume":"95","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072512184335400_BIB16","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/ana.10065","volume":"50","year":"2001","journal-title":"Ann. Neurol."},{"key":"2023072512184335400_BIB17","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/00005072-199307000-00010","volume":"52","year":"1993","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"2023072512184335400_BIB18","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1097\/00005072-199411000-00009","volume":"53","year":"1994","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"2023072512184335400_BIB19","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1056\/NEJM199703203361205","volume":"336","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"2023072512184335400_BIB20","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.1128\/jvi.64.11.5682-5687.1990","volume":"64","year":"1990","journal-title":"J. Virol."},{"key":"2023072512184335400_BIB21","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1182\/blood.V98.3.721","volume":"98","year":"2001","journal-title":"Blood."},{"key":"2023072512184335400_BIB22","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1182\/blood.V98.6.1858","volume":"98","year":"2001","journal-title":"Blood."},{"key":"2023072512184335400_BIB23","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S1074-7613(00)00065-0","volume":"13","year":"2000","journal-title":"Immunity."},{"key":"2023072512184335400_BIB24","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/00042560-199705010-00011","volume":"15","year":"1997","journal-title":"J. Acquir. Immune Defic. Syndr. Hum. Retrovirol."},{"key":"2023072512184335400_BIB25","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1038\/sj.onc.1205329","volume":"21","year":"2002","journal-title":"Oncogene."},{"key":"2023072512184335400_BIB26"},{"key":"2023072512184335400_BIB27","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0165-5728(99)00175-7","volume":"102","year":"2000","journal-title":"J. Neuroimmunol."},{"key":"2023072512184335400_BIB28","doi-asserted-by":"crossref","first-page":"9421","DOI":"10.1073\/pnas.132285699","volume":"99","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072512184335400_BIB29","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.4049\/jimmunol.170.8.4349","volume":"170","year":"2003","journal-title":"J. Immunol."},{"key":"2023072512184335400_BIB30","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.4049\/jimmunol.146.10.3508","volume":"146","year":"1991","journal-title":"J. Immunol."},{"key":"2023072512184335400_BIB31","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0198-8859(81)90065-3","volume":"3","year":"1981","journal-title":"Hum. Immunol."},{"key":"2023072512184335400_BIB32","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1182\/blood.V95.4.1386.004k22_1386_1392","volume":"95","year":"2000","journal-title":"Blood."},{"key":"2023072512184335400_BIB33","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1002\/j.1460-2075.1986.tb04583.x","volume":"5","year":"1986","journal-title":"EMBO J."},{"key":"2023072512184335400_BIB34","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.274.5284.94","volume":"274","year":"1996","journal-title":"Science."},{"key":"2023072512184335400_BIB35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0167-5699(98)01390-5","volume":"20","year":"1999","journal-title":"Immunol. Today."},{"key":"2023072512184335400_BIB36","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.1073\/pnas.77.12.7415","volume":"77","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072512184335400_BIB37","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1126\/science.6200936","volume":"224","year":"1984","journal-title":"Science."},{"key":"2023072512184335400_BIB38","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1073\/pnas.80.17.5402","volume":"80","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072512184335400_BIB39","first-page":"1472","volume":"2","year":"1984","journal-title":"Lancet."},{"key":"2023072512184335400_BIB40","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/312763a0","volume":"312","year":"1984","journal-title":"Nature."},{"key":"2023072512184335400_BIB41","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/312767a0","volume":"312","year":"1984","journal-title":"Nature."},{"key":"2023072512184335400_BIB42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/viro.2000.0143","volume":"268","year":"2000","journal-title":"Virology."},{"key":"2023072512184335400_BIB43","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1182\/blood-2002-09-2681","volume":"101","year":"2003","journal-title":"Blood."},{"key":"2023072512184335400_BIB44","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1073\/pnas.89.6.2110","volume":"89","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072512184335400_BIB45","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.4049\/jimmunol.157.7.2932","volume":"157","year":"1996","journal-title":"J. Immunol."},{"key":"2023072512184335400_BIB46","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/(SICI)1097-4547(19960915)45:6<786::AID-JNR15>3.0.CO;2-U","volume":"45","year":"1996","journal-title":"J. Neurosci. Res."},{"key":"2023072512184335400_BIB47","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0952-7915(00)00107-2","volume":"12","year":"2000","journal-title":"Curr. Opin. Immunol."},{"key":"2023072512184335400_BIB48","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nm845","volume":"9","year":"2003","journal-title":"Nat. Med."},{"key":"2023072512184335400_BIB49","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1034\/j.1600-065X.2001.1820102.x","volume":"182","year":"2001","journal-title":"Immunol. Rev."},{"key":"2023072512184335400_BIB50","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nri821","volume":"2","year":"2002","journal-title":"Nat. Rev. Immunol."}],"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/199\/10\/1367\/1712350\/jem199101367.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/199\/10\/1367\/1712350\/jem199101367.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T08:29:26Z","timestamp":1690273766000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/199\/10\/1367\/39899\/Increased-Expression-of-Human-T-Lymphocyte-Virus"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,10]]},"references-count":50,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,5,17]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20032042","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1019344.218497","asserted-by":"object"}]},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5,10]]}}}