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The potential role of CD25+CD4+ regulatory T cells (T reg cells), previously shown to inhibit immune responses directed against numerous pathogens, as suppressors of HIV-specific T cell responses was investigated. In the majority of healthy HIV-infected individuals, CD25+CD4+ T cells significantly suppressed cellular proliferation and cytokine production by CD4+ and CD8+ T cells in response to HIV antigens\/peptides in vitro; these effects were cell contact dependent and IL-10 and TGF-\u03b2 independent. Individuals with strong HIV-specific CD25+ T reg cell function in vitro had significantly lower levels of plasma viremia and higher CD4+: CD8+ T cell ratios than did those individuals in whom this activity could not be detected. These in vitro data suggest that CD25+CD4+ T reg cells may contribute to the diminution of HIV-specific T cell immune responses in vivo in the early stages of HIV disease.<\/jats:p>","DOI":"10.1084\/jem.20032069","type":"journal-article","created":{"date-parts":[[2004,7,26]],"date-time":"2004-07-26T20:13:57Z","timestamp":1090872837000},"page":"331-343","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":344,"title":["CD25+CD4+ Regulatory T Cells from the Peripheral Blood of Asymptomatic HIV-infected Individuals Regulate CD4+ and CD8+ HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status"],"prefix":"10.1084","volume":"200","author":[{"given":"Audrey L.","family":"Kinter","sequence":"first","affiliation":[{"name":"1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Hennessey","sequence":"additional","affiliation":[{"name":"1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Bell","sequence":"additional","affiliation":[{"name":"1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Kern","sequence":"additional","affiliation":[{"name":"1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Lin","sequence":"additional","affiliation":[{"name":"1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marybeth","family":"Daucher","sequence":"additional","affiliation":[{"name":"1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Planta","sequence":"additional","affiliation":[{"name":"2Department of Clinical Center Medicine, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"McGlaughlin","sequence":"additional","affiliation":[{"name":"1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Jackson","sequence":"additional","affiliation":[{"name":"1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven F.","family":"Ziegler","sequence":"additional","affiliation":[{"name":"3Benaroya Research Institute, Virginia Mason Medical Center, Seattle, WA 98111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony S.","family":"Fauci","sequence":"additional","affiliation":[{"name":"1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2004,7,26]]},"reference":[{"key":"2023072512435251000_BIB1","first-page":"275","volume":"95","year":"1987","journal-title":"Acta Pathol. 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