{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:54:20Z","timestamp":1791255260289,"version":"4.1.0"},"reference-count":30,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,3,1]]},"abstract":"<jats:p>The immune response to infection must be controlled to ensure it is optimal for defense while avoiding the consequences of excessive inflammation, which include fatal septic shock. Mice deficient in Fc\u03b3RIIb, an inhibitory immunoglobulin G Fc receptor, have enhanced immune responses. Therefore, we examined whether Fc\u03b3RIIb controls the response to Streptococcus pneumoniae. Macrophages from Fc\u03b3RIIb-deficient mice showed increased antibody-dependent phagocytosis of pneumococci in vitro, and consistent with this infected Fc\u03b3RIIb-deficient mice demonstrated increased bacterial clearance and survival. In contrast, previously immunized Fc\u03b3RIIb-deficient mice challenged with large inocula showed reduced survival. This correlated with increased production of the sepsis-associated cytokines tumor necrosis factor \u03b1 and interleukin 6. We propose that Fc\u03b3RIIb controls the balance between efficient pathogen clearance and the cytokine-mediated consequences of sepsis, with potential therapeutic implications.<\/jats:p>","DOI":"10.1084\/jem.20032197","type":"journal-article","created":{"date-parts":[[2004,2,24]],"date-time":"2004-02-24T01:56:28Z","timestamp":1077587788000},"page":"717-723","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":121,"title":["Fc\u03b3RIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis"],"prefix":"10.1084","volume":"199","author":[{"given":"Menna R.","family":"Clatworthy","sequence":"first","affiliation":[{"name":"The Cambridge Institute for Medical Research and the Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge CB2 2XY, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth G.C.","family":"Smith","sequence":"additional","affiliation":[{"name":"The Cambridge Institute for Medical Research and the Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge CB2 2XY, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2004,2,23]]},"reference":[{"key":"2023072512260023800_BIB1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1128\/iai.65.1.257-260.1997","volume":"65","year":"1997","journal-title":"Infect. Immun."},{"key":"2023072512260023800_BIB2","doi-asserted-by":"crossref","first-page":"6881","DOI":"10.1128\/IAI.69.11.6881-6886.2001","volume":"69","year":"2001","journal-title":"Infect. Immun."},{"key":"2023072512260023800_BIB3","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMra021333","volume":"348","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"2023072512260023800_BIB4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev.immunol.19.1.275","volume":"19","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"2023072512260023800_BIB5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1046\/j.1365-2567.2003.01592.x","volume":"108","year":"2003","journal-title":"Immunology."},{"key":"2023072512260023800_BIB6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/379346a0","volume":"379","year":"1996","journal-title":"Nature."},{"key":"2023072512260023800_BIB7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1084\/jem.189.1.179","volume":"189","year":"1999","journal-title":"J. Exp. Med."},{"key":"2023072512260023800_BIB8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1365-3083.2002.01124.x","volume":"56","year":"2002","journal-title":"Scand. J. Immunol."},{"key":"2023072512260023800_BIB9","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1084\/jem.153.3.694","volume":"153","year":"1981","journal-title":"J. Exp. Med."},{"key":"2023072512260023800_BIB10","doi-asserted-by":"crossref","first-page":"6375","DOI":"10.4049\/jimmunol.168.12.6375","volume":"168","year":"2002","journal-title":"J. Immunol."},{"key":"2023072512260023800_BIB11","doi-asserted-by":"crossref","first-page":"6702","DOI":"10.1128\/IAI.69.11.6702-6706.2001","volume":"69","year":"2001","journal-title":"Infect. Immun."},{"key":"2023072512260023800_BIB12"},{"key":"2023072512260023800_BIB13","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1128\/CDLI.6.4.581-586.1999","volume":"6","year":"1999","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"2023072512260023800_BIB14","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S1074-7613(01)00129-7","volume":"14","year":"2001","journal-title":"Immunity."},{"key":"2023072512260023800_BIB15","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1086\/375276","volume":"187","year":"2003","journal-title":"J. Infect. Dis."},{"key":"2023072512260023800_BIB16","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1128\/IAI.69.1.426-434.2001","volume":"69","year":"2001","journal-title":"Infect. Immun."},{"key":"2023072512260023800_BIB17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0882-4010(02)90524-3","volume":"33","year":"2002","journal-title":"Microb. Pathog."},{"key":"2023072512260023800_BIB18","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1126\/science.3764421","volume":"234","year":"1986","journal-title":"Science."},{"key":"2023072512260023800_BIB19","doi-asserted-by":"crossref","first-page":"771","DOI":"10.7326\/0003-4819-119-8-199310150-00001","volume":"119","year":"1993","journal-title":"Ann. Intern. Med."},{"key":"2023072512260023800_BIB20","first-page":"138","volume":"38","year":"1992","journal-title":"Circ. Shock."},{"key":"2023072512260023800_BIB21","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1084\/jem.179.3.849","volume":"179","year":"1994","journal-title":"J. Exp. Med."},{"key":"2023072512260023800_BIB22","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.4049\/jimmunol.161.5.2079","volume":"161","year":"1998","journal-title":"J. Immunol."},{"key":"2023072512260023800_BIB23","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1097\/00003246-199308000-00022","volume":"21","year":"1993","journal-title":"Crit. Care Med."},{"key":"2023072512260023800_BIB24","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1007\/s001340050903","volume":"25","year":"1999","journal-title":"Intensive Care Med."},{"key":"2023072512260023800_BIB25","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4049\/jimmunol.166.1.531","volume":"166","year":"2001","journal-title":"J. Immunol."},{"key":"2023072512260023800_BIB26","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1084\/jem.20011435","volume":"195","year":"2002","journal-title":"J. Exp. Med."},{"key":"2023072512260023800_BIB27","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/art.10257","volume":"46","year":"2002","journal-title":"Arthritis Rheum."},{"key":"2023072512260023800_BIB28","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1034\/j.1399-0039.2003.00047.x","volume":"61","year":"2003","journal-title":"Tissue Antigens."},{"key":"2023072512260023800_BIB29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0960-9822(00)00344-4","volume":"10","year":"2000","journal-title":"Curr. Biol."},{"key":"2023072512260023800_BIB30","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.4049\/jimmunol.169.8.4340","volume":"169","year":"2002","journal-title":"J. Immunol."}],"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/199\/5\/717\/1713249\/jem1995717.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/199\/5\/717\/1713249\/jem1995717.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T12:36:59Z","timestamp":1690288619000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/199\/5\/717\/40060\/Fc-RIIb-Balances-Efficient-Pathogen-Clearance-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2,23]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,3,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20032197","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[2004,2,23]]}}}