{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T21:55:19Z","timestamp":1775253319513,"version":"3.50.1"},"reference-count":47,"publisher":"Rockefeller University Press","issue":"10","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,5,17]]},"abstract":"<jats:p>Reduced levels of wild-type mannose-binding lectin (MBL) may increase susceptibility for infection, other common diseases, and death. We investigated associations between MBL deficiency and risk of infection, other common diseases, and death during 24, 24, and 8 yr of follow-up, respectively. We genotyped 9,245 individuals from the adult Danish population for three MBL deficiency alleles, B, C, and D, as opposed to the normal noncarrier A allele. Hospitalization incidence per 10,000 person \u00b7 yr was 644 in noncarriers compared with 631 in heterozygotes (log-rank: P = 0.39) and 658 in deficiency homozygotes (P = 0.53). Death incidence per 10,000 person \u00b7 yr was 235 in noncarriers compared with 244 in heterozygotes (P = 0.44) and 274 in deficiency homozygotes (P = 0.12). After stratification by specific cause of hospitalization or death, only hospitalization from cardiovascular disorders was increased in deficiency homozygotes versus noncarriers (P = 0.02). When retested in two case control studies, this association could not be confirmed. Incidence of hospitalization or death from infections or other serious common disorders did not differ between deficiency homozygotes and noncarriers. In conclusion, in this large study in an ethnically homogenous Caucasian population, there was no evidence for significant differences in infectious disease or mortality in MBL-deficient individuals versus controls. Our results suggest that MBL deficiency is not a major risk factor for morbidity or death in the adult Caucasian population.<\/jats:p>","DOI":"10.1084\/jem.20040111","type":"journal-article","created":{"date-parts":[[2004,5,17]],"date-time":"2004-05-17T18:43:01Z","timestamp":1084819381000},"page":"1391-1399","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":126,"title":["A Population-based Study of Morbidity and Mortality in Mannose-binding Lectin Deficiency"],"prefix":"10.1084","volume":"199","author":[{"given":"Morten","family":"Dahl","sequence":"first","affiliation":[{"name":"1Department of Clinical Biochemistry, Herlev University Hospital, DK-2730 Herlev, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Tybj\u00e6rg-Hansen","sequence":"additional","affiliation":[{"name":"2Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark"},{"name":"3The Copenhagen City Heart Study, Bispebjerg University Hospital, DK-2400 Copenhagen NV, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Schnohr","sequence":"additional","affiliation":[{"name":"3The Copenhagen City Heart Study, Bispebjerg University Hospital, DK-2400 Copenhagen NV, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00f8rge G.","family":"Nordestgaard","sequence":"additional","affiliation":[{"name":"1Department of Clinical Biochemistry, Herlev University Hospital, DK-2730 Herlev, Denmark"},{"name":"3The Copenhagen City Heart Study, Bispebjerg University Hospital, DK-2400 Copenhagen NV, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2004,5,17]]},"reference":[{"key":"2023072512131106600_BIB1","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/S0140-6736(96)07495-8","volume":"349","year":"1997","journal-title":"Lancet."},{"key":"2023072512131106600_BIB2","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0140-6736(96)07493-4","volume":"349","year":"1997","journal-title":"Lancet."},{"key":"2023072512131106600_BIB3","first-page":"1236","volume":"2","year":"1989","journal-title":"Lancet."},{"key":"2023072512131106600_BIB4","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1128\/IAI.68.2.688-693.2000","volume":"68","year":"2000","journal-title":"Infect. 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