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BadA mediates the binding of B. henselae to extracellular matrix proteins and to endothelial cells, possibly via \u03b21 integrins, but prevents phagocytosis. Expression of BadA is crucial for activation of hypoxia-inducible factor 1 in host cells by B. henselae and secretion of proangiogenic cytokines (e.g., vascular endothelial growth factor). BadA is immunodominant in B. henselae\u2013infected patients and rodents, indicating that it is expressed during Bartonella infections. Our results suggest that BadA, the largest characterized bacterial protein thus far, is a major pathogenicity factor of B. henselae with a potential role in the induction of vasculoproliferative disorders.<\/jats:p>","DOI":"10.1084\/jem.20040500","type":"journal-article","created":{"date-parts":[[2004,11,8]],"date-time":"2004-11-08T20:25:47Z","timestamp":1099945547000},"page":"1267-1278","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":198,"title":["<i>Bartonella<\/i>\n                    Adhesin A Mediates a Proangiogenic Host Cell Response"],"prefix":"10.1084","volume":"200","author":[{"given":"Tanja","family":"Riess","sequence":"first","affiliation":[{"name":"1Institut fu\u0308r Medizinische Mikrobiologie und Hygiene, Department of Molecular Biology, Eberhard-Karls-Universita\u0308t, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siv G.E.","family":"Andersson","sequence":"additional","affiliation":[{"name":"4Department of Molecular Evolution, Evolutionary Biology Center, Uppsala University, 75236 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Lupas","sequence":"additional","affiliation":[{"name":"5Max-Planck-Institut fu\u0308r Entwicklungsbiologie, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schaller","sequence":"additional","affiliation":[{"name":"2Universita\u0308ts-Hautklinik, Department of Molecular Biology, Eberhard-Karls-Universita\u0308t, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Scha\u0308fer","sequence":"additional","affiliation":[{"name":"1Institut fu\u0308r Medizinische Mikrobiologie und Hygiene, Department of Molecular Biology, Eberhard-Karls-Universita\u0308t, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Kyme","sequence":"additional","affiliation":[{"name":"1Institut fu\u0308r Medizinische Mikrobiologie und Hygiene, Department of Molecular Biology, Eberhard-Karls-Universita\u0308t, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u0308rg","family":"Martin","sequence":"additional","affiliation":[{"name":"5Max-Planck-Institut fu\u0308r Entwicklungsbiologie, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo-Hee","family":"Wa\u0308lzlein","sequence":"additional","affiliation":[{"name":"1Institut fu\u0308r Medizinische Mikrobiologie und Hygiene, Department of Molecular Biology, Eberhard-Karls-Universita\u0308t, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Ehehalt","sequence":"additional","affiliation":[{"name":"1Institut fu\u0308r Medizinische Mikrobiologie und Hygiene, Department of Molecular Biology, Eberhard-Karls-Universita\u0308t, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillevi","family":"Lindroos","sequence":"additional","affiliation":[{"name":"4Department of Molecular Evolution, Evolutionary Biology Center, Uppsala University, 75236 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Schirle","sequence":"additional","affiliation":[{"name":"3Institute for Cell Biology, Department of Molecular Biology, Eberhard-Karls-Universita\u0308t, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Nordheim","sequence":"additional","affiliation":[{"name":"3Institute for Cell Biology, Department of Molecular Biology, Eberhard-Karls-Universita\u0308t, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo B.","family":"Autenrieth","sequence":"additional","affiliation":[{"name":"1Institut fu\u0308r Medizinische Mikrobiologie und Hygiene, Department of Molecular Biology, Eberhard-Karls-Universita\u0308t, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkhard A.J.","family":"Kempf","sequence":"additional","affiliation":[{"name":"1Institut fu\u0308r Medizinische Mikrobiologie und Hygiene, Department of Molecular Biology, Eberhard-Karls-Universita\u0308t, 72076 Tu\u0308bingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2004,11,8]]},"reference":[{"key":"2023072512314069600_BIB1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1128\/CMR.10.2.203","volume":"10","year":"1997","journal-title":"Clin. 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