{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:02:21Z","timestamp":1791302541672,"version":"4.1.0"},"reference-count":22,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,7,19]]},"abstract":"<jats:p>The signaling lymphocytic activation molecule (SLAM)\/CD150 family includes a family of chromosome 1\u2013encoded cell surface molecules with costimulatory functions mediated in part by the adaptor protein SH2D1A (SLAM-associated protein, SAP). Deficiency in SH2D1A protects mice from an experimental model of lupus, including the development of hypergammaglobulinemia, autoantibodies including anti\u2013double stranded DNA, and renal disease. This protection did not reflect grossly defective T or B cell function per se because SH2D1A-deficient mice were susceptible to experimental autoimmune encephalomyelitis, a T cell\u2013dependent disease, and they were capable of mounting normal T-independent antigen-specific immunoglobulin responses. Instead, T-dependent antibody responses were impaired in SH2D1A-deficient mice, reflecting defective germinal center formation. These findings demonstrate a specific role for the SLAM\u2013SH2D1A system in the regulation of T-dependent humoral immune responses, implicating members of the CD150\u2013SH2D1A family as targets in the pathogenesis and therapy of antibody-mediated autoimmune and allergic diseases.<\/jats:p>","DOI":"10.1084\/jem.20040526","type":"journal-article","created":{"date-parts":[[2004,7,19]],"date-time":"2004-07-19T15:07:36Z","timestamp":1090249656000},"page":"261-266","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":91,"title":["SH2D1A Regulates T-dependent Humoral Autoimmunity"],"prefix":"10.1084","volume":"200","author":[{"given":"Jonathan D.","family":"Hron","sequence":"first","affiliation":[{"name":"1Department of Internal Medicine\/Rheumatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liron","family":"Caplan","sequence":"additional","affiliation":[{"name":"1Department of Internal Medicine\/Rheumatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea J.","family":"Gerth","sequence":"additional","affiliation":[{"name":"1Department of Internal Medicine\/Rheumatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela L.","family":"Schwartzberg","sequence":"additional","affiliation":[{"name":"3National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanford L.","family":"Peng","sequence":"additional","affiliation":[{"name":"1Department of Internal Medicine\/Rheumatology"},{"name":"2Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2004,7,19]]},"reference":[{"key":"2023072512345741100_BIB1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nri1202","volume":"3","year":"2003","journal-title":"Nat. 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Lett."},{"key":"2023072512345741100_BIB13","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.4049\/jimmunol.156.10.4041","volume":"156","year":"1996","journal-title":"J. Immunol."},{"key":"2023072512345741100_BIB14","doi-asserted-by":"crossref","first-page":"5689","DOI":"10.4049\/jimmunol.157.12.5689","volume":"157","year":"1996","journal-title":"J. Immunol."},{"key":"2023072512345741100_BIB15","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.4049\/jimmunol.163.5.2937","volume":"163","year":"1999","journal-title":"J. Immunol."},{"key":"2023072512345741100_BIB16","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1172\/JCI21357","volume":"113","year":"2004","journal-title":"J. Clin. Invest."},{"key":"2023072512345741100_BIB17","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.4049\/jimmunol.172.6.3369","volume":"172","year":"2004","journal-title":"J. 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