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Furthermore, this enhanced bacterial clearance is accompanied by a block in L. monocytogenes\u2013induced splenic apoptosis in IRF3- and IFNAR1-deficient mice. Thus, our results highlight the disparate roles of type I IFNs during bacterial versus viral infections and stress the importance of proper IFN modulation in host defense.<\/jats:p>","DOI":"10.1084\/jem.20040712","type":"journal-article","created":{"date-parts":[[2004,8,9]],"date-time":"2004-08-09T20:13:50Z","timestamp":1092082430000},"page":"437-445","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":411,"title":["Type I Interferon Production Enhances Susceptibility to\n                    <i>Listeria monocytogenes<\/i>\n                    Infection"],"prefix":"10.1084","volume":"200","author":[{"given":"Ryan M.","family":"O'Connell","sequence":"first","affiliation":[{"name":"1Department of Microbiology, Immunology and Molecular Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya K.","family":"Saha","sequence":"additional","affiliation":[{"name":"1Department of Microbiology, Immunology and Molecular Genetics"},{"name":"2Medical Scientist Training Program"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar A.","family":"Vaidya","sequence":"additional","affiliation":[{"name":"1Department of Microbiology, Immunology and Molecular Genetics"},{"name":"2Medical Scientist Training Program"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin W.","family":"Bruhn","sequence":"additional","affiliation":[{"name":"1Department of Microbiology, Immunology and Molecular Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo A.","family":"Miranda","sequence":"additional","affiliation":[{"name":"4Jonsson Comprehensive Cancer Center,"},{"name":"5Department of Obstetrics and Gynecology and Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Zarnegar","sequence":"additional","affiliation":[{"name":"1Department of Microbiology, Immunology and Molecular Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea K.","family":"Perry","sequence":"additional","affiliation":[{"name":"1Department of Microbiology, Immunology and Molecular Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bidong O.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"1Department of Microbiology, Immunology and Molecular Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy F.","family":"Lane","sequence":"additional","affiliation":[{"name":"4Jonsson Comprehensive Cancer Center,"},{"name":"5Department of Obstetrics and Gynecology and Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadatsugu","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"6Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff F.","family":"Miller","sequence":"additional","affiliation":[{"name":"1Department of Microbiology, Immunology and Molecular Genetics"},{"name":"3Molecular Biology Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genhong","family":"Cheng","sequence":"additional","affiliation":[{"name":"1Department of Microbiology, Immunology and Molecular Genetics"},{"name":"3Molecular Biology Institute"},{"name":"4Jonsson Comprehensive Cancer Center,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2004,8,9]]},"reference":[{"key":"2023072512395673000_BIB1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1098\/rspb.1957.0048","volume":"147","year":"1957","journal-title":"Proc. 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