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Furthermore, treatment of resting splenic lymphocytes with recombinant IFN-\u03b1A enhanced their susceptibility to LLO-induced apoptosis. Together, these data suggest that type I IFN signaling is detrimental to handling of a bacterial pathogen and may enhance the susceptibility of lymphocytes undergoing apoptosis in response to bacterial pore-forming toxins.<\/jats:p>","DOI":"10.1084\/jem.20040769","type":"journal-article","created":{"date-parts":[[2004,8,9]],"date-time":"2004-08-09T20:13:50Z","timestamp":1092082430000},"page":"535-540","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":329,"title":["Type I Interferon Sensitizes Lymphocytes to Apoptosis and Reduces Resistance to\n                    <i>Listeria<\/i>\n                    Infection"],"prefix":"10.1084","volume":"200","author":[{"given":"Javier A.","family":"Carrero","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Calderon","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil R.","family":"Unanue","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2004,8,9]]},"reference":[{"key":"2023072512344048600_BIB1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-065X.1997.tb00988.x","volume":"158","year":"1997","journal-title":"Immunol. 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