{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:32:08Z","timestamp":1791311528345,"version":"4.3.1"},"reference-count":29,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,8,16]]},"abstract":"<jats:p>Listeria monocytogenes is a facultative intracellular pathogen that induces a cytosolic signaling cascade resulting in expression of interferon (IFN)-\u03b2. Although type I IFNs are critical in viral defense, their role in immunity to bacterial pathogens is much less clear. In this study, we addressed the role of type I IFNs by examining the infection of L. monocytogenes in BALB\/c mice lacking the type I IFN receptor (IFN-\u03b1\/\u03b2R\u2212\/\u2212). During the first 24 h of infection in vivo, IFN-\u03b1\/\u03b2R\u2212\/\u2212 and wild-type mice were similar in terms of L. monocytogenes survival. In addition, the intracellular fate of L. monocytogenes in macrophages cultured from IFN-\u03b1\/\u03b2R\u2212\/\u2212 and wild-type mice was indistinguishable. However, by 72 h after inoculation in vivo, IFN-\u03b1\/\u03b2R\u2212\/\u2212 mice were \u223c1,000-fold more resistant to a high dose L. monocytogenes infection. Resistance was correlated with elevated levels of interleukin 12p70 in the blood and increased numbers of CD11b+ macrophages producing tumor necrosis factor \u03b1 in the spleen of IFN-\u03b1\/\u03b2R\u2212\/\u2212 mice. The results of this study suggest that L. monocytogenes might be exploiting an innate antiviral response to promote its pathogenesis.<\/jats:p>","DOI":"10.1084\/jem.20040976","type":"journal-article","created":{"date-parts":[[2004,8,9]],"date-time":"2004-08-09T20:13:50Z","timestamp":1092082430000},"page":"527-533","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":388,"title":["Mice Lacking the Type I Interferon Receptor Are Resistant to\n                    <i>Listeria monocytogenes<\/i>"],"prefix":"10.1084","volume":"200","author":[{"given":"Victoria","family":"Auerbuch","sequence":"first","affiliation":[{"name":"1Department of Molecular and Cell Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk G.","family":"Brockstedt","sequence":"additional","affiliation":[{"name":"3Cerus Corporation, Concord, CA 94520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Meyer-Morse","sequence":"additional","affiliation":[{"name":"1Department of Molecular and Cell Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"O'Riordan","sequence":"additional","affiliation":[{"name":"1Department of Molecular and Cell Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Portnoy","sequence":"additional","affiliation":[{"name":"1Department of Molecular and Cell Biology"},{"name":"2School of Public Health, University of California, Berkeley, Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2004,8,9]]},"reference":[{"key":"2023072512371355800_BIB1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S1359-6101(02)00023-0","volume":"13","year":"2002","journal-title":"Cytokine Growth Factor Rev."},{"key":"2023072512371355800_BIB2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1177\/09680519030090030501","volume":"9","year":"2003","journal-title":"J. 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