{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:25:17Z","timestamp":1791289517279,"version":"4.3.0"},"reference-count":56,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,9,19]]},"abstract":"<jats:p>This study investigated the unresolved issue of antigen-dependency and antigen-specificity of autoimmune disease suppression by CD4+CD25+ T cells (T regs). Based on autoimmune ovarian disease (AOD) in day 3 thymectomized (d3tx) mice and polyclonal T regs expressing the Thy1.1 marker, we determined: (a) the location of recipient T cell suppression, (b) the distribution of AOD-suppressing T regs, and (c) the relative efficacy of male versus female T regs. Expansion of recipient CD4+ T cells, activation\/memory marker expression, and IFN-\u03b3 production were inhibited persistently in the ovary-draining LNs but not elsewhere. The cellular changes were reversed upon Thy1.1+ T reg depletion, with emergence of potent pathogenic T cells and severe AOD. Similar changes were detected in the regional LNs during autoimmune dacryoadenitis and autoimmune prostatitis suppression. Although the infused Thy1.1+ T regs proliferated and were disseminated in peripheral lymphoid organs, only those retrieved from ovary-draining LNs adoptively suppressed AOD at a suboptimal cell dose. By depriving d3tx recipients of ovarian antigens, we unmasked the supremacy of ovarian antigen-exposed female over male T regs in AOD suppression. Thus, disease suppression by polyclonal T regs depends on endogenous antigen stimulation; this occurs in a location where potent antigen-specific T regs accumulate and continuously negate pathogenic T cell response.<\/jats:p>","DOI":"10.1084\/jem.20041033","type":"journal-article","created":{"date-parts":[[2005,9,19]],"date-time":"2005-09-19T15:18:07Z","timestamp":1127143087000},"page":"771-781","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":146,"title":["Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node"],"prefix":"10.1084","volume":"202","author":[{"given":"Eileen T.","family":"Samy","sequence":"first","affiliation":[{"name":"1Department of Pathology, University of Virginia, Charlottesville, VA 22908"},{"name":"2Department of Microbiology, University of Virginia, Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy A.","family":"Parker","sequence":"additional","affiliation":[{"name":"1Department of Pathology, University of Virginia, Charlottesville, VA 22908"},{"name":"2Department of Microbiology, University of Virginia, Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin P.","family":"Sharp","sequence":"additional","affiliation":[{"name":"1Department of Pathology, University of Virginia, Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth S.K.","family":"Tung","sequence":"additional","affiliation":[{"name":"1Department of Pathology, University of Virginia, Charlottesville, VA 22908"},{"name":"2Department of Microbiology, University of Virginia, Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2005,9,19]]},"reference":[{"key":"2023072513172131100_BIB1","first-page":"345","volume":"6","year":"2005","journal-title":"Nat. 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