{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:22:28Z","timestamp":1790940148454,"version":"4.1.0"},"reference-count":28,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,1,17]]},"abstract":"<jats:p>The immunostimulatory cytokine IL-12 is able to antagonize immunosuppression induced by solar\/ultraviolet (UV) radiation via yet unknown mechanisms. IL-12 was recently found to induce deoxyribonucleic acid (DNA) repair. UV-induced DNA damage is an important molecular trigger for UV-mediated immunosuppression. Thus, we initiated studies into immune restoration by IL-12 to discern whether its effects are linked to DNA repair. IL-12 prevented both UV-induced suppression of the induction of contact hypersensitivity and the depletion of Langerhans cells, the primary APC of the skin, in wild-type but not in DNA repair-deficient mice. IL-12 did not prevent the development of UV-induced regulatory T cells in DNA repair-deficient mice. In contrast, IL-12 was able to break established UV-induced tolerance and inhibited the activity of regulatory T cells independent of DNA repair. These data identify a new mechanism by which IL-12 can restore immune responses and also demonstrate a link between DNA repair and the prevention of UV-induced immunosuppression by IL-12.<\/jats:p>","DOI":"10.1084\/jem.20041212","type":"journal-article","created":{"date-parts":[[2005,1,18]],"date-time":"2005-01-18T20:44:02Z","timestamp":1106081042000},"page":"173-179","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":153,"title":["Prevention of UV radiation\u2013induced immunosuppression by IL-12 is dependent on DNA repair"],"prefix":"10.1084","volume":"201","author":[{"given":"Agatha","family":"Schwarz","sequence":"first","affiliation":[{"name":"1Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University Mu\u0308nster, D-48149 Mu\u0308nster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Maeda","sequence":"additional","affiliation":[{"name":"1Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University Mu\u0308nster, D-48149 Mu\u0308nster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Kernebeck","sequence":"additional","affiliation":[{"name":"1Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University Mu\u0308nster, D-48149 Mu\u0308nster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"van Steeg","sequence":"additional","affiliation":[{"name":"2National Institute of Public Health and the Environment, Laboratory of Health Effects Research, 3720 Bilthoven, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Beissert","sequence":"additional","affiliation":[{"name":"1Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University Mu\u0308nster, D-48149 Mu\u0308nster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schwarz","sequence":"additional","affiliation":[{"name":"1Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University Mu\u0308nster, D-48149 Mu\u0308nster, Germany"},{"name":"3Department of Dermatology, University Kiel, D-24105 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2005,1,18]]},"reference":[{"key":"2023072512511583200_BIB1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/379335a0","volume":"379","year":"1996","journal-title":"Nature."},{"key":"2023072512511583200_BIB2","first-page":"53","volume":"53","year":"1993","journal-title":"Cancer Res."},{"key":"2023072512511583200_BIB3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1751-1097.1995.tb03966.x","volume":"61","year":"1995","journal-title":"Photochem. 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