{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:27:41Z","timestamp":1791217661213,"version":"4.1.0"},"reference-count":48,"publisher":"Rockefeller University Press","issue":"10","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,5,16]]},"abstract":"<jats:p>A mouse cytomegalovirus (MCMV) gene conferring interferon (IFN) resistance was identified. This gene, M27, encodes a 79-kD protein that selectively binds and down-regulates for signal transducer and activator of transcription (STAT)-2, but it has no effect on STAT1 activation and signaling. The absence of pM27 conferred MCMV susceptibility to type I IFNs (\u03b1\/\u03b2), but it had a much more dramatic effect on type II IFNs (\u03b3) in vitro and in vivo. A comparative analysis of M27+ and M27\u2212 MCMV revealed that the antiviral efficiency of IFN-\u03b3 was partially dependent on the synergistic action of type I IFNs that required STAT2. Moreover, STAT2 was directly activated by IFN-\u03b3. This effect required IFN receptor expression and was independent of type I IFNs. IFN-\u03b3 induced increasing levels of tyrosine-phosphorylated STAT2 in M27\u2212 MCMV-infected cells that were essential for the antiviral potency of IFN-\u03b3. pM27 represents a new strategy for simultaneous evasions from types I and II IFNs, and it documents an unknown biological significance for STAT2 in antiviral IFN-\u03b3 responses.<\/jats:p>","DOI":"10.1084\/jem.20041401","type":"journal-article","created":{"date-parts":[[2005,5,10]],"date-time":"2005-05-10T00:24:12Z","timestamp":1115684652000},"page":"1543-1553","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":133,"title":["A cytomegaloviral protein reveals a dual role for STAT2 in IFN-\u03b3 signaling and antiviral responses"],"prefix":"10.1084","volume":"201","author":[{"given":"Albert","family":"Zimmermann","sequence":"first","affiliation":[{"name":"1Institut fu\u0308r Virologie, Heinrich-Heine-Universita\u0308t Du\u0308sseldorf, 40225 Du\u0308sseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Trilling","sequence":"additional","affiliation":[{"name":"2Division of Viral Infections, Robert Koch Institute, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Wagner","sequence":"additional","affiliation":[{"name":"3Department of Virology, Max von Pettenkofer Institute, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Wilborn","sequence":"additional","affiliation":[{"name":"2Division of Viral Infections, Robert Koch Institute, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Bubic","sequence":"additional","affiliation":[{"name":"4Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stipan","family":"Jonjic","sequence":"additional","affiliation":[{"name":"4Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Koszinowski","sequence":"additional","affiliation":[{"name":"3Department of Virology, Max von Pettenkofer Institute, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut","family":"Hengel","sequence":"additional","affiliation":[{"name":"1Institut fu\u0308r Virologie, Heinrich-Heine-Universita\u0308t Du\u0308sseldorf, 40225 Du\u0308sseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2005,5,9]]},"reference":[{"key":"2023072512523034700_BIB1","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.277.5332.1630","volume":"277","year":"1997","journal-title":"Science."},{"key":"2023072512523034700_BIB2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev.biochem.67.1.227","volume":"67","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"2023072512523034700_BIB3","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1128\/MCB.17.4.2048","volume":"17","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"2023072512523034700_BIB4","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.immunol.15.1.563","volume":"15","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"2023072512523034700_BIB5","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1128\/jvi.66.4.1977-1984.1992","volume":"66","year":"1992","journal-title":"J. Virol."},{"key":"2023072512523034700_BIB6","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1084\/jem.188.6.1047","volume":"188","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023072512523034700_BIB7","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1084\/jem.188.3.577","volume":"188","year":"1998","journal-title":"J. Exp. Med"},{"key":"2023072512523034700_BIB8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1128\/jvi.68.1.289-297.1994","volume":"68","year":"1994","journal-title":"J. Virol."},{"key":"2023072512523034700_BIB9","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0966-842X(98)01255-4","volume":"6","year":"1998","journal-title":"Trends Microbiol."},{"key":"2023072512523034700_BIB10","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1084\/jem.187.7.1037","volume":"187","year":"1998","journal-title":"J. Exp. Med"},{"key":"2023072512523034700_BIB11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1099\/0022-1317-75-1-101","volume":"75","year":"1994","journal-title":"J. Gen. Virol."},{"key":"2023072512523034700_BIB12","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1084\/jem.187.5.675","volume":"187","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023072512523034700_BIB13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1126\/science.291.5502.303","volume":"291","year":"2001","journal-title":"Science."},{"key":"2023072512523034700_BIB14","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1128\/JVI.75.4.1697-1707.2001","volume":"75","year":"2001","journal-title":"J. Virol."},{"key":"2023072512523034700_BIB15","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1146\/annurev.immunol.19.1.623","volume":"19","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"2023072512523034700_BIB16","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.1093\/emboj\/17.22.6660","volume":"17","year":"1998","journal-title":"EMBO J."},{"key":"2023072512523034700_BIB17","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/viro.2001.0856","volume":"283","year":"2001","journal-title":"Virology."},{"key":"2023072512523034700_BIB18","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1126\/science.1071545","volume":"296","year":"2002","journal-title":"Science."},{"key":"2023072512523034700_BIB19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(02)00398-0","volume":"285","year":"2002","journal-title":"Gene."},{"key":"2023072512523034700_BIB20","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1074-7613(00)00077-7","volume":"13","year":"2000","journal-title":"Immunity."},{"key":"2023072512523034700_BIB21","doi-asserted-by":"crossref","first-page":"6262","DOI":"10.1002\/j.1460-2075.1996.tb01016.x","volume":"15","year":"1996","journal-title":"EMBO J."},{"key":"2023072512523034700_BIB22","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1126\/science.288.5475.2357","volume":"288","year":"2000","journal-title":"Science."},{"key":"2023072512523034700_BIB23","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1074-7613(00)00054-6","volume":"13","year":"2000","journal-title":"Immunity."},{"key":"2023072512523034700_BIB24","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1515\/BC.1999.087","volume":"380","year":"1999","journal-title":"Biol. Chem."},{"key":"2023072512523034700_BIB25","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1126\/science.8009221","volume":"264","year":"1994","journal-title":"Science."},{"key":"2023072512523034700_BIB26","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1099\/0022-1317-81-10-2341","volume":"81","year":"2000","journal-title":"J. Gen. Virol."},{"key":"2023072512523034700_BIB27","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1128\/JVI.78.4.1831-1842.2004","volume":"78","year":"2004","journal-title":"J. Virol."},{"key":"2023072512523034700_BIB28","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/j.1460-2075.1996.tb00445.x","volume":"15","year":"1996","journal-title":"EMBO J."},{"key":"2023072512523034700_BIB29","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1128\/JVI.76.10.4912-4918.2002","volume":"76","year":"2002","journal-title":"J. Virol."},{"key":"2023072512523034700_BIB30","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.4049\/jimmunol.162.10.6107","volume":"162","year":"1999","journal-title":"J. Immunol."},{"key":"2023072512523034700_BIB31","doi-asserted-by":"crossref","first-page":"11541","DOI":"10.1128\/JVI.76.22.11541-11550.2002","volume":"76","year":"2002","journal-title":"J. Virol."},{"key":"2023072512523034700_BIB32","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1089\/jir.1995.15.897","volume":"15","year":"1995","journal-title":"J. Interferon Cytokine Res."},{"key":"2023072512523034700_BIB33","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1146\/annurev.immunol.15.1.749","volume":"15","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"2023072512523034700_BIB34","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.4049\/jimmunol.158.7.3303","volume":"158","year":"1997","journal-title":"J. Immunol."},{"key":"2023072512523034700_BIB35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4049\/jimmunol.169.1.167","volume":"169","year":"2002","journal-title":"J. Immunol."},{"key":"2023072512523034700_BIB36","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/00007890-200002270-00040","volume":"69","year":"2000","journal-title":"Transplantation."},{"key":"2023072512523034700_BIB37","doi-asserted-by":"crossref","first-page":"14309","DOI":"10.1073\/pnas.1835673100","volume":"100","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072512523034700_BIB38","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0960-9822(98)70086-7","volume":"8","year":"1998","journal-title":"Curr. Biol."},{"key":"2023072512523034700_BIB39"},{"key":"2023072512523034700_BIB40","doi-asserted-by":"crossref","first-page":"7056","DOI":"10.1128\/JVI.73.8.7056-7060.1999","volume":"73","year":"1999","journal-title":"J. Virol."},{"key":"2023072512523034700_BIB41","doi-asserted-by":"crossref","first-page":"7720","DOI":"10.1128\/JVI.74.17.7720-7729.2000","volume":"74","year":"2000","journal-title":"J. Virol."},{"key":"2023072512523034700_BIB42","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1084\/jem.20020811","volume":"196","year":"2002","journal-title":"J. Exp. Med."},{"key":"2023072512523034700_BIB43","doi-asserted-by":"crossref","first-page":"8596","DOI":"10.1128\/JVI.76.17.8596-8608.2002","volume":"76","year":"2002","journal-title":"J. Virol."},{"key":"2023072512523034700_BIB44","doi-asserted-by":"crossref","first-page":"14759","DOI":"10.1073\/pnas.94.26.14759","volume":"94","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072512523034700_BIB45","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S1074-7613(00)80350-7","volume":"6","year":"1997","journal-title":"Immunity."},{"key":"2023072512523034700_BIB46","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/emboj\/21.3.344","volume":"21","year":"2002","journal-title":"EMBO J."},{"key":"2023072512523034700_BIB47","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1093\/nar\/27.21.4191","volume":"27","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"2023072512523034700_BIB48","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1099\/0022-1317-76-12-2987","volume":"76","year":"1995","journal-title":"J. Gen. Virol."}],"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/201\/10\/1543\/1716182\/jem201101543.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/201\/10\/1543\/1716182\/jem201101543.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T12:59:16Z","timestamp":1690289956000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/201\/10\/1543\/40160\/A-cytomegaloviral-protein-reveals-a-dual-role-for"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,9]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2005,5,16]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20041401","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5,9]]}}}