{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:15:28Z","timestamp":1790705728368,"version":"4.1.0"},"reference-count":48,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,2,21]]},"abstract":"<jats:p>The pre\u2013T cell receptor (TCR) is expressed early during T cell development and imposes a tight selection for differentiating T cell progenitors. Pre-TCR\u2013expressing cells are selected to survive and differentiate further, whereas pre-TCR\u2212 cells are \u201cnegatively\u201d selected to die. The mechanisms of pre-TCR\u2013mediated survival are poorly understood. Here, we describe the induction of the antiapoptotic gene BCL2A1 (A1) as a potential mechanism regulating inhibition of pre\u2013T cell death. We characterize in detail the signaling pathway involved in A1 induction and show that A1 expression can induce pre\u2013T cell survival by inhibiting activation of caspase-3. Moreover, we show that in vitro \u201cknockdown\u201d of A1 expression can compromise survival even in the presence of a functional pre-TCR. Finally, we suggest that pre-TCR\u2013induced A1 overexpression can contribute to T cell leukemia in both mice and humans.<\/jats:p>","DOI":"10.1084\/jem.20041924","type":"journal-article","created":{"date-parts":[[2005,2,22]],"date-time":"2005-02-22T17:18:27Z","timestamp":1109092707000},"page":"603-614","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":105,"title":["The BCL2A1 gene as a pre\u2013T cell receptor\u2013induced regulator of thymocyte survival"],"prefix":"10.1084","volume":"201","author":[{"given":"Malay","family":"Mandal","sequence":"first","affiliation":[{"name":"1Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Borowski","sequence":"additional","affiliation":[{"name":"2Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Palomero","sequence":"additional","affiliation":[{"name":"3Department of Pediatric Oncology, Dana-Farber Cancer Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo A.","family":"Ferrando","sequence":"additional","affiliation":[{"name":"3Department of Pediatric Oncology, Dana-Farber Cancer Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Oberdoerffer","sequence":"additional","affiliation":[{"name":"5Center for Blood Research, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanyong","family":"Meng","sequence":"additional","affiliation":[{"name":"1Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ruiz-Vela","sequence":"additional","affiliation":[{"name":"4Howard Hughes Medical Institute, Dana-Farber Cancer Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ciofani","sequence":"additional","affiliation":[{"name":"6Department of Immunology, University of Toronto, Sunnybrook and Women's College Health Sciences Center, Toronto M4N 3M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Carlos","family":"Zuniga-Pflucker","sequence":"additional","affiliation":[{"name":"6Department of Immunology, University of Toronto, Sunnybrook and Women's College Health Sciences Center, Toronto M4N 3M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Screpanti","sequence":"additional","affiliation":[{"name":"7Department of Experimental Medicine and Pathology, University La Sapienza, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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