{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:17:35Z","timestamp":1790907455611,"version":"4.1.0"},"reference-count":52,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,9,5]]},"abstract":"<jats:p>C57BL\/6 (B6) and B6 background STAT6\u2212\/\u2212 mice pretreated with IL-18 plus IL-2 showed prominent intestinal mastocytosis and rapidly expelled implanted adult worms of the gastrointestinal nematode Strongyloides venezuelensis. In contrast, identically pretreated mast cell\u2013deficient W\/Wv mice failed to do so. Thus, activated mucosal mast cells (MMC) are crucial for parasite expulsion. B6 mice infected with S. venezuelensis third-stage larvae (L3) completed parasite expulsion by day 12 after infection, whereas IL-18\u2212\/\u2212 or IL-18R\u03b1\u2212\/\u2212 B6 mice exhibited marked impairment in parasite expulsion, suggesting a substantial contribution of IL-18\u2013dependent MMC activation to parasite expulsion. Compared with IL-18\u2212\/\u2212 or IL-18R\u03b1\u2212\/\u2212 mice, S. venezuelensis L3\u2013infected STAT6\u2212\/\u2212 mice have poorly activated MMC and sustained infection; although their IL-18 production is normal. Neutralization of IL-18 and IL-2 further reduces expulsion in infected STAT6\u2212\/\u2212 mice. These results suggest that collaboration between IL-18\u2013dependent and Th2 cell\u2013dependent mastocytosis is important for prompt parasite expulsion.<\/jats:p>","DOI":"10.1084\/jem.20042202","type":"journal-article","created":{"date-parts":[[2005,8,29]],"date-time":"2005-08-29T20:13:17Z","timestamp":1125346397000},"page":"607-616","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":86,"title":["IL-18 with IL-2 protects against\n                    <i>Strongyloides venezuelensis<\/i>\n                    infection by activating mucosal mast cell\u2013dependent type 2 innate immunity"],"prefix":"10.1084","volume":"202","author":[{"given":"Yuki","family":"Sasaki","sequence":"first","affiliation":[{"name":"1Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, 663-8501, Japan"},{"name":"2Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, 332-0012, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"1Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, 663-8501, Japan"},{"name":"2Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, 332-0012, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Maruyama","sequence":"additional","affiliation":[{"name":"3Department of Medical Zoology, Nagoya City University Medical School, Nagoya, 467-8601, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Tegoshi","sequence":"additional","affiliation":[{"name":"4Department of Medical Zoology, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Ohta","sequence":"additional","affiliation":[{"name":"3Department of Medical Zoology, Nagoya City University Medical School, Nagoya, 467-8601, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Arizono","sequence":"additional","affiliation":[{"name":"4Department of Medical Zoology, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"1Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, 663-8501, Japan"},{"name":"2Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, 332-0012, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2005,8,29]]},"reference":[{"key":"2023072513164752000_BIB1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev.immunol.15.1.505","volume":"15","year":"1997","journal-title":"Annu. 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