{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:50:50Z","timestamp":1791618650627,"version":"4.3.4"},"reference-count":74,"publisher":"Rockefeller University Press","issue":"8","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,4,18]]},"abstract":"<jats:p>We analyzed the structure of antigen receptors of a comprehensive panel of mature B non-Hodgkin's lymphomas (B-NHLs) by comparing, at the amino acid level, their immunoglobulin (Ig)VH-CDR3s with CDR3 sequences present in GenBank. Follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas, and myelomas expressed a CDR3 repertoire comparable to that of normal B cells. Mantle cell lymphomas and B cell chronic lymphocytic leukemias (B-CLLs) expressed clearly restricted albeit different CDR3 repertoires. Lymphomas of mucosa-associated lymphoid tissues (MALTs) were unique as 8 out of 45 (18%) of gastric- and 13 out of 32 (41%) of salivary gland-MALT lymphomas expressed B cell antigen receptors with strong CDR3 homology to rheumatoid factors (RFs). Of note, the RF-CDR3 homology without exception included N-region\u2013encoded residues in the hypermutated IgVH genes, indicating that they were stringently selected for reactivity with auto-IgG. By in vitro binding studies with 10 MALT lymphoma\u2013derived antibodies, we showed that seven of these cases, of which four with RF-CDR3 homology, indeed possessed strong RF reactivity. Of one MALT lymphoma, functional proof for selection of subclones with high RF affinity was obtained. Interestingly, RF-CDR3 homology and t(11;18) appeared to be mutually exclusive features and RF-CDR3 homology was not encountered in any of the 19 pulmonary MALT lymphomas studied.<\/jats:p>","DOI":"10.1084\/jem.20050068","type":"journal-article","created":{"date-parts":[[2005,4,18]],"date-time":"2005-04-18T19:33:35Z","timestamp":1113852815000},"page":"1229-1241","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":188,"title":["Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity"],"prefix":"10.1084","volume":"201","author":[{"given":"Richard J.","family":"Bende","sequence":"first","affiliation":[{"name":"1Department of Pathology, Academic Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelmina M.","family":"Aarts","sequence":"additional","affiliation":[{"name":"1Department of Pathology, Academic Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Riedl","sequence":"additional","affiliation":[{"name":"1Department of Pathology, Academic Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"de Jong","sequence":"additional","affiliation":[{"name":"2Department of Pathology, Netherlands Cancer Institute, 1105 AZ Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven T.","family":"Pals","sequence":"additional","affiliation":[{"name":"1Department of Pathology, Academic Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carel J.M.","family":"van Noesel","sequence":"additional","affiliation":[{"name":"1Department of Pathology, Academic Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2005,4,18]]},"reference":[{"key":"2023072513003414900_BIB1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1600-065X.1998.tb01447.x","volume":"162","year":"1998","journal-title":"Immunol. 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