{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:25:40Z","timestamp":1791275140534,"version":"4.1.0"},"reference-count":25,"publisher":"Rockefeller University Press","issue":"12","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,6,20]]},"abstract":"<jats:p>Cerebrospinal meningitis is a feared disease that can cause the death of a previously healthy individual within hours. Paradoxically, the causative agent, Neisseria meningitidis, is a common inhabitant of the human nasopharynx, and as such, may be considered a normal, commensal organism. Only in a small proportion of colonized people do the bacteria invade the bloodstream, from where they can cross the blood\u2013brain barrier to cause meningitis. Furthermore, most meningococcal disease is caused by bacteria belonging to only a few of the phylogenetic groups among the large number that constitute the population structure of this genetically variable organism. However, the genetic basis for the differences in pathogenic potential remains elusive. By performing whole genome comparisons of a large collection of meningococcal isolates of defined pathogenic potential we brought to light a meningococcal prophage present in disease-causing bacteria. The phage, of the filamentous family, excises from the chromosome and is secreted from the bacteria via the type IV pilin secretin. Therefore, this element, by spreading among the population, may promote the development of new epidemic clones of N. meningitidis that are capable of breaking the normal commensal relationship with humans and causing invasive disease.<\/jats:p>","DOI":"10.1084\/jem.20050112","type":"journal-article","created":{"date-parts":[[2005,6,20]],"date-time":"2005-06-20T16:13:12Z","timestamp":1119283992000},"page":"1905-1913","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":174,"title":["A chromosomally integrated bacteriophage in invasive meningococci"],"prefix":"10.1084","volume":"201","author":[{"given":"Emmanuelle","family":"Bille","sequence":"first","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Medicale U570, Faculte\u0301 de Me\u0301decine Necker, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Ralph","family":"Zahar","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Medicale U570, Faculte\u0301 de Me\u0301decine Necker, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Perrin","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Medicale U570, Faculte\u0301 de Me\u0301decine Necker, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Morelle","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Medicale U570, Faculte\u0301 de Me\u0301decine Necker, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Kriz","sequence":"additional","affiliation":[{"name":"2National Reference Laboratory for Meningococcal Infections, National Institute of Public Health, 100 42 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Jolley","sequence":"additional","affiliation":[{"name":"3The Peter Medawar Building for Pathogen Research and Department of Zoology, Oxford, OX1 3SY, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin C.J.","family":"Maiden","sequence":"additional","affiliation":[{"name":"3The Peter Medawar Building for Pathogen Research and Department of Zoology, Oxford, OX1 3SY, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Dervin","sequence":"additional","affiliation":[{"name":"4Institut National Agronomique Paris-Grignon, 75231 Paris, Cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Nassif","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Medicale U570, Faculte\u0301 de Me\u0301decine Necker, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin R.","family":"Tinsley","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Medicale U570, Faculte\u0301 de Me\u0301decine Necker, 75015 Paris, France"},{"name":"4Institut National Agronomique Paris-Grignon, 75231 Paris, Cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2005,6,20]]},"reference":[{"key":"2023072512480089000_BIB1","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1084\/jem.129.6.1307","volume":"129","year":"1969","journal-title":"J. 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