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Expression of Kb or Dd conveyed strong rejection of MHC class I\u2013deficient cells, whereas the expression of Db or Ld resulted in weaker responses. The educating impact of weak ligands (Db and Ld) was further attenuated by the introduction of additional MHC class I alleles, whereas strong ligands (Kb and Dd) maintained their educating impact under such conditions. An analysis of activating and inhibitory receptors in single MHC class I mice suggested that the educating impact of a given MHC class I molecule was controlled both by the number of NK cells affected and by the strength of each MHC class I\u2013Ly49 receptor interaction, indicating that NK cell education may be regulated by a combination of qualitative and quantitative events.<\/jats:p>","DOI":"10.1084\/jem.20050167","type":"journal-article","created":{"date-parts":[[2005,4,4]],"date-time":"2005-04-04T18:57:38Z","timestamp":1112641058000},"page":"1145-1155","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":136,"title":["Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules"],"prefix":"10.1084","volume":"201","author":[{"given":"Sofia","family":"Johansson","sequence":"first","affiliation":[{"name":"1Microbiology and Tumor Biology Center, Karolinska Institutet, S-17177 Stockholm, Sweden"},{"name":"2Strategic Research Center IRIS for studies of Integrative Recognition in the Immune System, Karolinska Institutet, S-17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Johansson","sequence":"additional","affiliation":[{"name":"1Microbiology and Tumor Biology Center, Karolinska Institutet, S-17177 Stockholm, Sweden"},{"name":"2Strategic Research Center IRIS for studies of Integrative Recognition in the Immune System, Karolinska Institutet, S-17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftheria","family":"Rosmaraki","sequence":"additional","affiliation":[{"name":"1Microbiology and Tumor Biology Center, Karolinska Institutet, S-17177 Stockholm, Sweden"},{"name":"2Strategic Research Center IRIS for studies of Integrative Recognition in the Immune System, Karolinska Institutet, S-17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustaf","family":"Vahlne","sequence":"additional","affiliation":[{"name":"1Microbiology and Tumor Biology Center, Karolinska Institutet, S-17177 Stockholm, Sweden"},{"name":"2Strategic Research Center IRIS for studies of Integrative Recognition in the Immune System, Karolinska Institutet, S-17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramit","family":"Mehr","sequence":"additional","affiliation":[{"name":"2Strategic Research Center IRIS for studies of Integrative Recognition in the Immune System, Karolinska Institutet, S-17177 Stockholm, Sweden"},{"name":"3Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mali","family":"Salmon-Divon","sequence":"additional","affiliation":[{"name":"2Strategic Research Center IRIS for studies of Integrative Recognition in the Immune System, Karolinska Institutet, S-17177 Stockholm, Sweden"},{"name":"3Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franc\u0327ois","family":"Lemonnier","sequence":"additional","affiliation":[{"name":"4Unite\u0301 d'Immunite\u0301 Cellulaire Antivirale, Institut Pasteur, 75715 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klas","family":"Ka\u0308rre","sequence":"additional","affiliation":[{"name":"1Microbiology and Tumor Biology Center, Karolinska Institutet, S-17177 Stockholm, Sweden"},{"name":"2Strategic Research Center IRIS for studies of Integrative Recognition in the Immune System, Karolinska Institutet, S-17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petter","family":"Ho\u0308glund","sequence":"additional","affiliation":[{"name":"1Microbiology and Tumor Biology Center, Karolinska Institutet, S-17177 Stockholm, Sweden"},{"name":"2Strategic Research Center IRIS for studies of Integrative Recognition in the Immune System, Karolinska Institutet, S-17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2005,4,4]]},"reference":[{"key":"2023072513020566000_BIB1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/319675a0","volume":"319","year":"1986","journal-title":"Nature."},{"key":"2023072513020566000_BIB2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1034\/j.1600-065X.2001.1810113.x","volume":"181","year":"2001","journal-title":"Immunol. 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