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Transfer of naive CD4 T cells during early phases of infection resulted in a robust expansion of highly differentiated effectors, which then contracted to a small number of memory T cells. Importantly, T cell transfer during later phases of infection resulted in a modest expansion of effectors with intermediate phenotypes, which were capable of persisting as memory with high efficiency. Thus, distinct stages of pathogen-derived Ag presentation may provide a mechanism by which T cell heterogeneity is generated and diverse memory subsets are maintained.<\/jats:p>","DOI":"10.1084\/jem.20050227","type":"journal-article","created":{"date-parts":[[2005,9,7]],"date-time":"2005-09-07T00:45:35Z","timestamp":1126053935000},"page":"697-706","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":207,"title":["Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation"],"prefix":"10.1084","volume":"202","author":[{"given":"Dawn M.","family":"Jelley-Gibbs","sequence":"first","affiliation":[{"name":"Trudeau Institute Inc., Saranac Lake, NY 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Trudeau Institute Inc., Saranac Lake, NY 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Dibble","sequence":"additional","affiliation":[{"name":"Trudeau Institute Inc., Saranac Lake, NY 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Haynes","sequence":"additional","affiliation":[{"name":"Trudeau Institute Inc., Saranac Lake, NY 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheri M.","family":"Eaton","sequence":"additional","affiliation":[{"name":"Trudeau Institute Inc., Saranac Lake, NY 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Swain","sequence":"additional","affiliation":[{"name":"Trudeau Institute Inc., Saranac Lake, NY 12983"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2005,9,6]]},"reference":[{"key":"2023072513200601700_BIB1","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.4049\/jimmunol.164.6.3095","volume":"164","year":"2000","journal-title":"J. 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