{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:33:21Z","timestamp":1791239601453,"version":"4.1.0"},"reference-count":36,"publisher":"Rockefeller University Press","issue":"8","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,4,18]]},"abstract":"<jats:p>The mutation pattern of immunoglobulin genes was studied in mice deficient for DNA polymerase \u03b7, a translesional polymerase whose inactivation is responsible for the xeroderma pigmentosum variant (XP-V) syndrome in humans. Mutations show an 85% G\/C biased pattern, similar to that reported for XP-V patients. Breeding these mice with animals harboring the stop codon mutation of the 129\/Olain background in their DNA polymerase \u03b9 gene did not alter this pattern further. Although this G\/C biased mutation profile resembles that of mice deficient in the MSH2 or MSH6 components of the mismatch repair complex, the residual A\/T mutagenesis of pol\u03b7-deficient mice differs markedly. This suggests that, in the absence of pol\u03b7, the MSH2\u2013MSH6 complex is able to recruit another DNA polymerase that is more accurate at copying A\/T bases, possibly pol\u03ba, to assume its function in hypermutation.<\/jats:p>","DOI":"10.1084\/jem.20050292","type":"journal-article","created":{"date-parts":[[2005,4,11]],"date-time":"2005-04-11T20:23:47Z","timestamp":1113251027000},"page":"1191-1196","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":185,"title":["Contribution of DNA polymerase \u03b7 to immunoglobulin gene hypermutation in the mouse"],"prefix":"10.1084","volume":"201","author":[{"given":"Fre\u0301de\u0301ric","family":"Delbos","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Medicale U373, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades-Universite\u0301 Paris V, 75730 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"De Smet","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Medicale U373, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades-Universite\u0301 Paris V, 75730 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Faili","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Medicale U373, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades-Universite\u0301 Paris V, 75730 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said","family":"Aoufouchi","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Medicale U373, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades-Universite\u0301 Paris V, 75730 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Weill","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Medicale U373, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades-Universite\u0301 Paris V, 75730 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude-Agne\u0300s","family":"Reynaud","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Medicale U373, Faculte\u0301 de Me\u0301decine Necker-Enfants Malades-Universite\u0301 Paris V, 75730 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2005,4,11]]},"reference":[{"key":"2023072513042318600_BIB1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0092-8674(00)00078-7","volume":"102","year":"2000","journal-title":"Cell."},{"key":"2023072513042318600_BIB2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.it.2004.12.004","volume":"26","year":"2005","journal-title":"Trends Immunol."},{"key":"2023072513042318600_BIB3","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1126\/science.1071556","volume":"296","year":"2002","journal-title":"Science."},{"key":"2023072513042318600_BIB4","first-page":"631","volume":"4","year":"2003","journal-title":"Nat. Immunol."},{"key":"2023072513042318600_BIB5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.molcel.2004.10.011","volume":"16","year":"2004","journal-title":"Mol. Cell."},{"key":"2023072513042318600_BIB6","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/S0960-9822(02)01215-0","volume":"12","year":"2002","journal-title":"Curr. Biol."},{"key":"2023072513042318600_BIB7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1074-7613(00)80595-6","volume":"9","year":"1998","journal-title":"Immunity."},{"key":"2023072513042318600_BIB8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1074-7613(00)80594-4","volume":"9","year":"1998","journal-title":"Immunity."},{"key":"2023072513042318600_BIB9","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1084\/jem.187.11.1745","volume":"187","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023072513042318600_BIB10","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1084\/jem.191.3.579","volume":"191","year":"2000","journal-title":"J. Exp. Med."},{"key":"2023072513042318600_BIB11","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1084\/jem.20030880","volume":"198","year":"2003","journal-title":"J. Exp. Med."},{"key":"2023072513042318600_BIB12","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/ni1031","volume":"5","year":"2004","journal-title":"Nat. Immunol."},{"key":"2023072513042318600_BIB13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1084\/jem.20040691","volume":"200","year":"2004","journal-title":"J. Exp. Med."},{"key":"2023072513042318600_BIB14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1568-7864(02)00224-0","volume":"2","year":"2003","journal-title":"DNA Repair (Amst.)."},{"key":"2023072513042318600_BIB15","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/21447","volume":"399","year":"1999","journal-title":"Nature."},{"key":"2023072513042318600_BIB16","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/88740","volume":"2","year":"2001","journal-title":"Nat. Immunol."},{"key":"2023072513042318600_BIB17","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1084\/jem.20031831","volume":"199","year":"2004","journal-title":"J. Exp. Med."},{"key":"2023072513042318600_BIB18","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1084\/jem.20032022","volume":"199","year":"2004","journal-title":"J. Exp. Med."},{"key":"2023072513042318600_BIB19","doi-asserted-by":"crossref","first-page":"6246","DOI":"10.1093\/emboj\/cdf618","volume":"21","year":"2002","journal-title":"EMBO J."},{"key":"2023072513042318600_BIB20","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nature01117","volume":"419","year":"2002","journal-title":"Nature."},{"key":"2023072513042318600_BIB21","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1084\/jem.20030767","volume":"198","year":"2003","journal-title":"J. Exp. Med."},{"key":"2023072513042318600_BIB22","doi-asserted-by":"crossref","first-page":"327","DOI":"10.4049\/jimmunol.167.1.327","volume":"167","year":"2001","journal-title":"J. Immunol."},{"key":"2023072513042318600_BIB23","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S1074-7613(01)00142-X","volume":"14","year":"2001","journal-title":"Immunity."},{"key":"2023072513042318600_BIB24","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1128\/MCB.21.6.2018-2025.2001","volume":"21","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"2023072513042318600_BIB25","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.biochi.2003.10.009","volume":"85","year":"2003","journal-title":"Biochimie."},{"key":"2023072513042318600_BIB26","doi-asserted-by":"crossref","first-page":"39678","DOI":"10.1074\/jbc.M005309200","volume":"275","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2023072513042318600_BIB27","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1093\/nar\/28.21.4147","volume":"28","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"2023072513042318600_BIB28","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1002\/1521-4141(200211)32:11<3152::AID-IMMU3152>3.0.CO;2-2","volume":"32","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"2023072513042318600_BIB29","doi-asserted-by":"crossref","first-page":"7995","DOI":"10.1128\/MCB.21.23.7995-8006.2001","volume":"21","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"2023072513042318600_BIB30","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1093\/emboj\/cdg161","volume":"22","year":"2003","journal-title":"EMBO J."},{"key":"2023072513042318600_BIB31","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/nature02821","volume":"430","year":"2004","journal-title":"Nature."},{"key":"2023072513042318600_BIB32","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1073\/pnas.0303971101","volume":"101","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072513042318600_BIB33","doi-asserted-by":"crossref","first-page":"8835","DOI":"10.1128\/JVI.78.16.8835-8843.2004","volume":"78","year":"2004","journal-title":"J. Virol."},{"key":"2023072513042318600_BIB34","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1126\/science.8016642","volume":"265","year":"1994","journal-title":"Science."},{"key":"2023072513042318600_BIB35"},{"key":"2023072513042318600_BIB36","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.4049\/jimmunol.168.8.3702","volume":"168","year":"2002","journal-title":"J. Immunol."}],"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/201\/8\/1191\/1717361\/jem20181191.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/201\/8\/1191\/1717361\/jem20181191.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T09:09:15Z","timestamp":1690276155000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/201\/8\/1191\/52598\/Contribution-of-DNA-polymerase-to-immunoglobulin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,11]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,4,18]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.20050292","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4,11]]}}}